Back to table of contents Previous article Next article No AccessEnhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorderPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.150.1.83AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: The authors investigated the possibility of enhanced negative feedback sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis in posttraumatic stress disorder (PTSD) by using a low dose of dexamethasone. METHOD: Baseline blood samples were obtained at 8:00 a.m., and 0.5 mg of dexamethasone was administered to 21 male patients with PTSD and 12 normal age-comparable men at 11:00 p.m. Cortisol and dexamethasone levels were measured 9 and 17 hours after dexamethasone administration. RESULTS: After correction for differences in dexamethasone levels, the PTSD patients showed greater suppression of cortisol in response to dexamethasone than did the normal subjects. This was true even in patients meeting concurrent diagnostic criteria for major depression. CONCLUSIONS: The data support earlier studies showing that HPA abnormalities in PTSD are different from those seen in depression and suggest that the low-dose dexamethasone suppression test may be a potentially useful tool for differentiating the two syndromes and further exploring differences in their pathophysiology. Access content To read the fulltext, please use one of the options below to sign in or purchase access. 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Friedman, M.D., Ph.D. and His Legacy of Leadership in the Field of Post-traumatic Stress Disorder19 May 2022 | Psychiatry, Vol. 85, No. 2New Metabolic, Digestive, and Oxidative Stress-Related Manifestations Associated with Posttraumatic Stress DisorderOxidative Medicine and Cellular Longevity, Vol. 2021The Neurocircuitry of Posttraumatic Stress Disorder and Major Depression: Insights Into Overlapping and Distinct Circuit Dysfunction—A Tribute to Ron DumanBiological Psychiatry, Vol. 90, No. 2Sex, Pramipexole and Tiagabine Affect Behavioral and Hormonal Response to Traumatic Stress in a Mouse Model of PTSD30 June 2021 | Frontiers in Pharmacology, Vol. 12Is PTSD-Phenotype Associated with HPA-Axis Sensitivity? Feedback Inhibition and Other Modulating Factors of Glucocorticoid Signaling Dynamics3 June 2021 | International Journal of Molecular Sciences, Vol. 22, No. 11The impact of psychopathology, social adversity and stress-relevant DNA methylation on prospective risk for post-traumatic stress: A machine learning approachJournal of Affective Disorders, Vol. 282Posttraumatic Stress Disorder13 March 2021Brain-Derived Neurotrophic Factor and Its Role in Stress-Related DisordersRepeated unpredictable stress and social isolation induce chronic HPA axis dysfunction and persistent abnormal fear memoryProgress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 104Gut Microbiota and Pathophysiology of Depressive Disorder28 July 2021 | Annals of Nutrition and Metabolism, Vol. 77, No. Suppl. 2Abuso sessuale e PTSD complesso: gli effetti dello stress traumatico cronico sul sistema immunitario. Strategie d'interventoRIVISTA DI SESSUOLOGIA CLINICA, No. 1Low glucocorticoids in stress-related disorders: the role of inflammation22 May 2020 | Stress, Vol. 23, No. 6Hypothalamic-pituitary-adrenal axis activity in post-traumatic stress disorder and cocaine use disorder24 August 2020 | Stress, Vol. 23, No. 6Interoception, Stress, and Physical Symptoms in Stress-Associated DiseasesEuropean Journal of Health Psychology, Vol. 27, No. 4Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders3 January 2020 | Molecular Psychiatry, Vol. 25, No. 10A novel stress re-stress model: modification of re-stressor cue induces long-lasting post-traumatic stress disorder-like symptoms in rats12 January 2020 | International Journal of Neuroscience, Vol. 130, No. 9Hypothalamic-pituitary axis response to a 0.25-MG dexamethasone test in women with fibromyalgia18 October 2019 | Stress, Vol. 23, No. 3Perinatal exposure to bisphenol A at the intersection of stress, anxiety, and depressionNeurotoxicology and Teratology, Vol. 79Nervous and Endocrine System Dysfunction in Posttraumatic Stress Disorder: An Overview and Consideration of Sex as a Biological VariableBiological Psychiatry: Cognitive Neuroscience and Neuroimaging, Vol. 5, No. 4Confederates in the AtticJournal of Nervous & Mental Disease, Vol. 208, No. 3Finding intestinal fortitude: Integrating the microbiome into a holistic view of depression mechanisms, treatment, and resilienceNeurobiology of Disease, Vol. 135The glucocorticoid receptor–FKBP51 complex contributes to fear conditioning and posttraumatic stress disorder13 January 2020 | Journal of Clinical Investigation, Vol. 130, No. 2Dexamethasone Suppression Test20 October 2020Genomics and proteomics in brain complexity in relation to chemically induced posttraumatic stress disorderStress, the brain, and trauma spectrum disordersThe hypothalamic-pituitary-adrenal axis as a substrate for stress resilience: Interactions with the circadian clockFrontiers in Neuroendocrinology, Vol. 56Region- and time-dependent gene regulation in the amygdala and anterior cingulate cortex of a PTSD-like mouse model28 March 2019 | Molecular Brain, Vol. 12, No. 1Translating Molecular and Neuroendocrine Findings in Posttraumatic Stress Disorder and Resilience to Novel TherapiesBiological Psychiatry, Vol. 86, No. 6Social isolation as a promising animal model of PTSD comorbid suicide: neurosteroids and cannabinoids as possible treatment optionsProgress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 92CRF Mediates Stress-Induced Pathophysiological High-Frequency Oscillations in Traumatic Brain Injury30 April 2019 | eneuro, Vol. 6, No. 2Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Vol. 4, No. 3Physiology & Behavior, Vol. 198Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 89Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 90Frontiers in Psychology, Vol. 10Glucocorticoids and Hippocampal Structure and Function in PTSDHarvard Review of Psychiatry, Vol. 26, No. 3The Impact of Stressor Exposure and Glucocorticoids on Anxiety and Fear25 October 2018Posttraumatic Stress Disorder14 September 2018Current Psychiatry Reports, Vol. 20, No. 7Behavioural Brain Research, Vol. 338Neuroscience & Biobehavioral Reviews, Vol. 94Psychoneuroendocrinology, Vol. 91Psychological Medicine, Vol. 48, No. 14Development and Psychopathology, Vol. 30, No. 5Neurochemical Journal, Vol. 12, No. 2Pain Research and Management, Vol. 2018PLOS ONE, Vol. 13, No. 2PLOS ONE, Vol. 13, No. 12Frontiers in Behavioral Neuroscience, Vol. 12Persistent effects of acute stress on fear and drug-seeking in a novel model of the comorbidity between post-traumatic stress disorder and addiction16 August 2017 | Learning & Memory, Vol. 24, No. 9Dexamethasone-suppressed Salivary Cortisol and Pain Sensitivity in Female TwinsThe Clinical Journal of Pain, Vol. 33, No. 3Post-Traumatic Stress Disorder: The Relationship Between the Fear Response and Chronic Stress27 June 2017 | Chronic Stress, Vol. 1European Journal of Pain, Vol. 21, No. 7, Vol. 38, Vol. 1598Invloed van langdurige vroegkinderlijke negatieve ervaringen op de ontwikkeling van de borderlinepersoonlijkheidsstoornis23 June 2017Current Psychiatry Reports, Vol. 19, No. 10Neuroscience Letters, Vol. 649Neuroscience Letters, Vol. 647Psychoneuroendocrinology, Vol. 76Psychoneuroendocrinology, Vol. 78Journal of Cellular and Molecular Medicine, Vol. 21, No. 10Stress-related disorders, pituitary adenylate cyclase—activating peptide (PACAP)ergic system, and sex differences1 April 2022 | Dialogues in Clinical Neuroscience, Vol. 18, No. 4New translational perspectives for blood-based biomarkers of PTSD: From glucocorticoid to immune mediators of stress susceptibilityExperimental Neurology, Vol. 284Context Processing and the Neurobiology of Post-Traumatic Stress DisorderNeuron, Vol. 92, No. 1Severe, multimodal stress exposure induces PTSD-like characteristics in a mouse model of single prolonged stressBehavioural Brain Research, Vol. 303Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice16 June 2015 | Molecular Psychiatry, Vol. 21, No. 3Traumatic Stress From a Multilevel Developmental Psychopathology Perspective10 February 2016Endocrine Aspects of PTSD: Hypothalamic-Pituitary-Adrenal (HPA) Axis and Beyond2 June 2016Experimental Neurology, Vol. 284Neurobiology of Disease, Vol. 92Stress, Vol. 19, No. 4Social Cognitive and Affective Neuroscience, Vol. 11, No. 4PLOS ONE, Vol. 11, No. 10Journal of Neurogastroenterology and Motility, Vol. 22, No. 2Endocrine Aspects of PTSD: Hypothalamic-Pituitary-Adrenal (HPA) Axis and Beyond9 September 2015Genomics and Proteomics in Brain Complexity in Relation to Chemically Induced PTSDBehavioural Brain Research, Vol. 283Biological Psychiatry, Vol. 78, No. 5Clinical Therapeutics, Vol. 37, No. 3Psychoneuroendocrinology, Vol. 57Molecular BioSystems, Vol. 11, No. 4Psychiatry and Clinical Neurosciences, Vol. 69, No. 10International Journal of Endocrinology and Metabolism, Vol. 13, No. 4Neurobiological Risk Factors and Predictors of Vulnerability and Resilience to PTSDAn Ingeneious Study of Intergenerational Transmission of the Effects of PTSDDavid Spiegel, M.D.1 August 2014 | American Journal of Psychiatry, Vol. 171, No. 8Current Psychiatry Reports, Vol. 16, No. 11Psychoneuroendocrinology, Vol. 39Psychoneuroendocrinology, Vol. 40The International Journal of Neuropsychopharmacology, Vol. 17, No. 02Psychiatric Disturbances of Attention10 July 2013Current status on behavioral and biological markers of PTSD: A search for clarity in a conflicting literatureNeuroscience & Biobehavioral Reviews, Vol. 37, No. 5Sex dependent influence of a functional polymorphism in steroid 5-α-reductase type 2 ( SRD5A2 ) on post-traumatic stress symptoms15 March 2013 | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 162, No. 3Enhanced cortisol suppression following administration of low-dose dexamethasone in first-episode psychosis patients21 November 2012 | Australian & New Zealand Journal of Psychiatry, Vol. 47, No. 4Journal of Family Violence, Vol. 28, No. 1Tijdschrift voor Kindergeneeskunde, Vol. 81, No. 1Biological Psychology, Vol. 92, No. 2Psychoneuroendocrinology, Vol. 38, No. 9Post-Traumatic Stress DisorderCardiology in Review, Vol. 21, No. 1Acta Physiologica Hungarica, Vol. 100, No. 4Patterns of endogenous steroids in apathetic refugee children are compatible with long-term stress23 April 2012 | BMC Research Notes, Vol. 5, No. 1Neurocircuitry of Anxiety Disorders: Focus on Panic Disorder and Post-traumatic Stress DisorderSingle prolonged stress disrupts retention of extinguished fear in rats12 January 2012 | Learning & Memory, Vol. 19, No. 2Human Brain Mapping, Vol. 33, No. 9Psycho-Oncology, Vol. 21, No. 6Biological Psychiatry, Vol. 71, No. 4Clinical Psychology Review, Vol. 32, No. 4Neuropharmacology, Vol. 62, No. 2Psychoneuroendocrinology, Vol. 37, No. 3Psychoneuroendocrinology, Vol. 37, No. 5Psychoneuroendocrinology, Vol. 37, No. 7Psychoneuroendocrinology, Vol. 37, No. 9Psychoneuroendocrinology, Vol. 37, No. 9Neuropsychopharmacology, Vol. 37, No. 2Cerebral Cortex, Vol. 22, No. 10BMC Ear, Nose and Throat Disorders, Vol. 12, No. 1PLoS Computational Biology, Vol. 8, No. 2PLoS ONE, Vol. 7, No. 3Childhood Sexual Abuse, HPA Axis Regulation, and Mental Health9 December 2010 | Western Journal of Nursing Research, Vol. 33, No. 8Implications of Hypothalamic–Pituitary–Adrenal Axis Functioning in Posttraumatic Stress Disorder22 October 2011 | Journal of the American Psychiatric Nurses Association, Vol. 17, No. 6BibliographiePelvic pain in women: clinical and scientific aspectsCurrent Opinion in Supportive & Palliative Care, Vol. 5, No. 2Neurological Sciences, Vol. 32, No. 4Behavioural Brain Research, Vol. 222, No. 1Journal of Anxiety Disorders, Vol. 25, No. 3Neurochemistry International, Vol. 59, No. 6Psychoneuroendocrinology, Vol. 36, No. 7Hormones and Behavior, Vol. 59, No. 3Development and Psychopathology, Vol. 23, No. 2CNS Neuroscience & Therapeutics, Vol. 17, No. 6Retrospective Evaluation of the Dexamethasone Suppression Test as a Predictor of Response to Electroconvulsive Therapy in Patients With Comorbid Major Depressive Disorder and Posttraumatic Stress DisorderThe Journal of ECT, Vol. 26, No. 3How the Neurocircuitry and Genetics of Fear Inhibition May Inform Our Understanding of PTSDTanja Jovanovic, Ph.D., and Kerry J. Ressler, M.D., Ph.D.1 June 2010 | American Journal of Psychiatry, Vol. 167, No. 6Bibliographie, Vol. 182Journal of Psychiatric Research, Vol. 44, No. 1Journal of Psychiatric Research, Vol. 44, No. 14Neuroscience Letters, Vol. 480, No. 1Psychoneuroendocrinology, Vol. 35, No. 1Psychological Medicine, Vol. 40, No. 12Psychiatry and Clinical Neurosciences, Vol. 64, No. 5Bouncing back: trauma and the HPA-axis in healthy adults31 December 2010 | European Journal of Psychotraumatology, Vol. 1, No. 1The Neurobiological Toll of Child Abuse and Neglect6 August 2009 | Trauma, Violence, & Abuse, Vol. 10, No. 4Doing no harm: A commentary on ‘The clinical significance of co-morbid post-traumatic stress disorder and borderline personality disorder: Case study and literature review’14 July 2009 | Personality and Mental Health, Vol. 3, No. 3Enhanced negative feedback sensitivity of the hypothalamus-pituitary-adrenal axis in chronic myogenous facial pain⋆9 January 2012 | European Journal of Pain, Vol. 13, No. 6Differential Patterns of HPA Activity and Reactivity in Adult Posttraumatic Stress Disorder and Major Depressive DisorderHarvard Review of Psychiatry, Vol. 17, No. 3Autism Research, Vol. 2, No. 1Depression and Anxiety, Vol. 26, No. 121 De invloed van langdurige vroegkinderlijke negatieve ervaringen in de ontwikkeling van de borderline-persoonlijkheidsstoornis: een neurobiologisch perspectiefMetabolic Brain Disease, Vol. 24, No. 4Neuroendocrine Aspects of Post-Traumatic Stress DisorderNeuroImage, Vol. 47, No. 3NeuroImage, Vol. 47, No. 3Neuropsychopharmacology, Vol. 34, No. 3The Journal of Dermatology, Vol. 36, No. 1Annals of the New York Academy of Sciences, Vol. 1179, No. 1Arquivos Brasileiros de Endocrinologia & Metabologia, Vol. 53, No. 1Ecological Salivary Cortisol Analysis— Part 21 August 2008 | Journal of the American Psychiatric Nurses Association, Vol. 14, No. 4Activation of the serotonin 5-HT2C receptor is involved in the enhanced anxiety in rats after single-prolonged stressPharmacology Biochemistry and Behavior, Vol. 89, No. 1Biological Psychology, Vol. 78, No. 1Journal of Psychiatric Research, Vol. 42, No. 8Journal of Psychiatric Research, Vol. 42, No. 14Psychoneuroendocrinology, Vol. 33, No. 4Psychoneuroendocrinology, Vol. 33, No. 6Psychological Medicine, Vol. 38, No. 7BMC Public Health, Vol. 8, No. 1Cortisol, Dehydroepiandrosterone, and Estradiol Measured Over 24 Hours in Women With Childhood Sexual Abuse-Related Posttraumatic Stress DisorderJournal of Nervous & Mental Disease, Vol. 195, No. 11Long lasting sex-specific effects upon behavior and S100b levels after maternal separation and exposure to a model of post-traumatic stress disorder in ratsBrain Research, Vol. 1144Single prolonged stress increases contextual freezing and the expression of glycine transporter 1 and vesicle-associated membrane protein 2 mRNA in the hippocampus of ratsProgress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 31, No. 3Depersonalization Experiences in Undergraduates Are Related to Heightened Stress Cortisol ResponsesJournal of Nervous & Mental Disease, Vol. 195, No. 4NEUROBIOLOGICAL PERSPECTIVES ON TRAUMADoes Stress Damage the Brain?Depression and Anxiety, Vol. 24, No. 1Journal of Clinical Psychology, Vol. 63, No. 9De invloed van langdurige vroegkinderlijke negatieve ervaringen in de ontwikkeling van de borderline persoonlijkheidsstoornis: een neurobiologisch perspectief, Vol. 167EMC - Psychiatrie, Vol. 4, No. 3Biological Psychiatry, Vol. 61, No. 8Journal of Psychosomatic Research, Vol. 62, No. 1Neuroscience, Vol. 148, No. 1Psychoneuroendocrinology, Vol. 32, No. 3British Journal of Psychiatry, Vol. 191, No. 5Journal of Psychiatric Research, Vol. 40, No. 1Journal of Psychiatric Research, Vol. 40, No. 6Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 30, No. 3Psychoneuroendocrinology, Vol. 31, No. 4Psychoneuroendocrinology, Vol. 31, No. 10Psychoneuroendocrinology, Vol. 31, No. 10Development and Psychopathology, Vol. 18, No. 01Neuropsychopharmacology, Vol. 31, No. 1Addiction Biology, Vol. 11, No. 1Annals of the New York Academy of Sciences, Vol. 1071, No. 1Annals of the New York Academy of Sciences, Vol. 1071, No. 1Annals of the New York Academy of Sciences, Vol. 1071, No. 1Annals of the New York Academy of Sciences, Vol. 1071, No. 1Annals of the New York Academy of Sciences, Vol. 1071, No. 1International Journal of Occupational Medicine and Environmental Health, Vol. 19, No. 2Earthquake-Related PTSD: A Follow-up Study in Prevalence, Comorbidity, Quality of Life, and Biological CorrelatesReduced reactivity and enhanced negative feedback sensitivity of the hypothalamus–pituitary–adrenal axis in chronic whiplash-associated disorder☆Pain, Vol. 119, No. 1-3Evidence for Ototopical Glucocorticoid-Induced Decrease in Hypothalamic-Pituitary-Adrenal Axis Response and Liver FunctionEndocrinology, Vol. 146, No. 7Enhanced Cortisol Suppression Following Dexamethasone Administration in Domestic Violence SurvivorsMichael G. Griffin, Ph.D., Patricia A. Resick, Ph.D., and Rachel Yehuda, Ph.D.1 June 2005 | American Journal of Psychiatry, Vol. 162, No. 6Intimate Partner Violence and Post-Traumatic Stress Disorder Symptoms in Women2 July 2016 | Journal of Interpersonal Violence, Vol. 20, No. 4Predicting the failure of disc surgery by a hypofunctional HPA axis: evidence from a prospective study on patients undergoing disc surgeryPain, Vol. 114, No. 1Symptoms of Posttraumatic Stress Disorder and Borderline Personality Disorder in Veterans of Operation Desert StormSeth R. Axelrod, Ph.D., C. Andrew MorganIII, M.D., and Steven M. Southwick, M.D.1 February 2005 | American Journal of Psychiatry, Vol. 162, No. 2, Vol. 169, Vol. 15, Vol. 15Brain Research Reviews, Vol. 49, No. 3Clinical Neuroscience Research, Vol. 4, No. 5-6European Neuropsychopharmacology, Vol. 15, No. 2NeuroToxicology, Vol. 26, No. 2Psychoneuroendocrinology, Vol. 30, No. 2Psychoneuroendocrinology, Vol. 30, No. 9Journal of Occupational Health Psychology, Vol. 10, No. 2Neuropsychopharmacology, Vol. 30, No. 6The ACTH Response to Dexamethasone in PTSDRachel Yehuda, Ph.D., Julia A. Golier, M.D., Sarah L. Halligan, Ph.D., Michael Meaney, Ph.D., and Linda M. Bierer, M.D.1 August 2004 | American Journal of Psychiatry, Vol. 161, No. 8Current Concepts in Pharmacotherapy for Posttraumatic Stress DisorderFrank B. Schoenfeld, M.D., Charles R. Marmar, M.D., and Thomas C. Neylan, M.D.1 May 2004 | Psychiatric Services, Vol. 55, No. 5Biological Psychiatry, Vol. 55, No. 1Psychoneuroendocrinology, Vol. 29, No. 3Biological Psychiatry, Vol. 55, No. 7Biological Psychiatry, Vol. 55, No. 9Biological Psychiatry, Vol. 56, No. 3Clinica Chimica Acta, Vol. 342, No. 1-2Clinical Psychology Review, Vol. 24, No. 1Journal of Affective Disorders, Vol. 82, No. 1Psychiatry Research, Vol. 129, No. 1Journal of Abnormal Psychology, Vol. 113, No. 2Neuropsychobiology, Vol. 50, No. 4Neuroanatomical circuits modulating fear and anxiety behaviors29 August 2003 | Acta Psychiatrica Scandinavica, Vol. 108Brain Systems Underlying Susceptibility to Helplessness and Depression18 May 2016 | Behavioral and Cognitive Neuroscience Reviews, Vol. 2, No. 3Cortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abusePsychoneuroendocrinology, Vol. 28, No. 6Dexamethasone Suppression Test Findings in Subjects With Personality Disorders: Associations With Posttraumatic Stress Disorder and Major DepressionRobert Grossman, M.D., Rachel Yehuda, Ph.D., Antonia New, M.D., James Schmeidler, Ph.D., Jeremy Silverman, Ph.D., Vivian Mitropoulou, M.A., Nelly Sta. Maria, Ph.D., Julia Golier, M.D., and Larry Siever, M.D.1 July 2003 | American Journal of Psychiatry, Vol. 160, No. 7Current Psychiatry Reports, Vol. 5, No. 4European Journal of Pharmacology, Vol. 463, No. 1-3Journal of Psychiatric Research, Vol. 37, No. 3, Vol. 66Brain, Behavior, and Immunity, Vol. 17, No. 1Child and Adolescent Psychiatric Clinics of North America, Vol. 12, No. 2Neuropsychopharmacology, Vol. 28, No. 1Neuropsychopharmacology, Vol. 28, No. 9Neuropsychopharmacology, Vol. 28, No. 9Neuropsychoanalysis, Vol. 5, No. 1Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 42, No. 11, Vol. 20035180Journal of Trauma & Dissociation, Vol. 4, No. 4Revista Brasileira de Psiquiatria, Vol. 25, No. suppl 1Adult Neuroendocrine Aspects of PTSDPsychiatric Annals, Vol. 33, No. 1Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuseBiological Psychiatry, Vol. 52, No. 11References26 April 2013Stress Hormones: How Do They Measure Up?25 July 2016 | Biological Research For Nursing, Vol. 4, No. 2Altered Responsiveness of the Hypothalamus-Pituitary-Adrenal Axis and the Sympathetic Adrenomedullary System to Stress in Patients with Atopic DermatitisThe Journal of Clinical Endocrinology & Metabolism, Vol. 87, No. 9Longitudinal course of salivary cortisol in post-traumatic stress disorder23 September 2008 | Acta Psychiatrica Scandinavica, Vol. 105, No. 2Depression and Anxiety, Vol. 16, No. 1Biological Psychiatry, Vol. 52, No. 5Psychiatric Clinics of North America, Vol. 25, No. 2Psychiatric Clinics of North America, Vol. 25, No. 2Child and Adolescent Psychiatric Clinics of North America, Vol. 11, No. 4British Journal of Psychiatry, Vol. 181, No. 02New England Journal of Medicine, Vol. 346, No. 2Neurotoxicity Research, Vol. 4, No. 5-6Counselling and Psychotherapy Research, Vol. 2, No. 1Psychosomatic Medicine, Vol. 64, No. 2British Journal of Psychiatry, Vol. 181, No. 2Journal of Aggression, Maltreatment & Trauma, Vol. 6, No. 1Post-traumatic stress disorder: a review of psychobiology and pharmacotherapy4 March 2010 | Acta Psychiatrica Scandinavica, Vol. 104, No. 6Differential Responsivity of the Hypothalamic-Pituitary-Adrenal Axis to Glucocorticoid Negative-Feedback and Corticotropin Releasing Hormone in Rats Undergoing Morphine Withdrawal: Possible Mechanisms Involved in Facilitated and Attenuated Stress Response7 July 2008 | Journal of Neuroendocrinology, Vol. 13, No. 10Posttraumatic Stress Disorder, Trauma Exposure, and the Current Health of Canadian Bus Drivers1 March 2001 | The Canadian Journal of Psychiatry, Vol. 46, No. 2Cytokine, Vol. 13, No. 4Biological Psychiatry, Vol. 50, No. 4Biological Psychiatry, Vol. 50, No. 12Journal of Psychosomatic Research, Vol. 50, No. 5Medical Clinics of North America, Vol. 85, No. 3Neuroscience & Biobehavioral Reviews, Vol. 25, No. 2Psychiatry Research, Vol. 102, No. 3Peptides, Vol. 22, No. 5Journal of Traumatic Stress, Vol. 14, No. 2Current Opinion in Psychiatry, Vol. 14, No. 6Psychosomatic Medicine, Vol. 63, No. 6Nos névroses traumatiques ont-elles un avenir ?The Neurobiology of Fear: Relevance to Panic Disorder and Posttraumatic Stress DisorderPsychiatric Annals, Vol. 30, No. 12Treatment for Posttraumatic Stress Disorder28 June 2016 | Annals of Pharmacotherapy, Vol. 34, No. 3Journal of Psychosomatic Research, Vol. 48, No. 6Psychiatry Research, Vol. 95, No. 1Psychoneuroendocrinology, Vol. 25, No. 1Sleep Medicine Reviews, Vol. 4, No. 2Journal of the American Academy of Psychoanalysis, Vol. 28, No. 2Biological Factors Associated with Susceptibility to Posttraumatic Stress Disorder1 February 1999 | The Canadian Journal of Psychiatry, Vol. 44, No. 1Biological Psychiatry, Vol. 45, No. 7Biological Psychiatry, Vol. 45, No. 7Biological Psychiatry, Vol. 46, No. 11Journal of Psychiatric Research, Vol. 33, No. 3Psychosomatics, Vol. 40, No. 3Psychoneuroendocrinology, Vol. 24, No. 5Journal of Neuroendocrinology, Vol. 11, No. 1Childhood Posttraumatic Stress Disorder: A Review of Neurobiologic SequelaePsychiatric Annals, Vol. 28, No. 8Biological Psychiatry, Vol. 43, No. 5Biological Psychiatry, Vol. 43, No. 11Biological Psychiatry, Vol. 44, No. 10Biological Psychiatry, Vol. 44, No. 1Psychiatric Clinics of North America, Vol. 21, No. 2CNS Spectrums, Vol. 3, No. S2CNS Spectrums, Vol. 3, No. S2Scandinavian Journal of Gastroenterology, Vol. 33, No. 7Journal of Women's Health, Vol. 7, No. 9Psychosomatic Medicine, Vol. 60, No. 3Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder1 April 2006 | American Journal of Psychiatry, Vol. 154, No. 5Integrative Physiological and Behavioral Science, Vol. 32, No. 4Biological Psychiatry, Vol. 42, No. 5Biological Psychiatry, Vol. 42, No. 8Journal of Psychiatric Research, Vol. 31, No. 1Psychoneuroendocrinology, Vol. 22, No. 6Annals of the New York Academy of Sciences, Vol. 821, No. 1 PsychobiologyAnnals of the New York Academy of Sciences, Vol. 821, No. 1 PsychobiologyAnnals of the New York Academy of Sciences, Vol. 821, No. 1 PsychobiologyAnnals of the New York Academy of Sciences, Vol. 821, No. 1 PsychobiologyAnnals of the New York Academy of Sciences, Vol. 821, No. 1 PsychobiologyAnnals of the New York Academy of Sciences, Vol. 821, No. 1 PsychobiologyBritish Journal of Psychiatry, Vol. 170, No. 5Stress, Vol. 1, No. 3Basal cortisol, dexamethasone suppression of cortisol, and MHPG in adolescents after the 1988 earthquake in Armenia1 April 2006 | American Journal of Psychiatry, Vol. 153, No. 7Platelet imipramine binding in patients with posttraumatic stress disorder before and after phenelzine treatmentPsychiatry Research, Vol. 63, No. 2-3Biological Psychiatry, Vol. 39, No. 3Biological Psychiatry, Vol. 40, No. 2Biological Psychiatry, Vol. 40, No. 11The Journal of Nervous and Mental Disease, Vol. 184, No. 5Psychosomatic Medicine, Vol. 58, No. 2Conflict between current knowledge about posttraumatic stress disorder and its original conceptual basis1 April 2006 | American Journal of Psychiatry, Vol. 152, No. 12The Neurobiology of Posttraumatic Stress Disorder29 June 2016 | Journal of the American Psychiatric Nurses Association, Vol. 1, No. 6Low urinary cortisol excretion in Holocaust survivors with posttraumatic stress disorder1 April 2006 | American Journal of Psychiatry, Vol. 152, No. 7Biological Psychiatry, Vol. 38, No. 12Life Sciences, Vol. 57, No. 2Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 34, No. 8Psychosomatic Medicine, Vol. 57, No. 2Annals of the New York Academy of Sciences, Vol. 771, No. 1 StressLife Sciences, Vol. 54, No. 3Psychiatry Research, Vol. 51, No. 1Psychiatric Clinics of North America, Vol. 17, No. 2Psychiatric Clinics of North America, Vol. 17, No. 2Child and Adolescent Psychiatric Clinics of North America, Vol. 3, No. 4Medical Journal of Australia, Vol. 160, No. 7The Dexamethasone Suppression Test in Psychiatric DisordersPsychiatric Annals, Vol. 23, No. 12Biological Psychiatry, Vol. 33, No. 7Biological Psychiatry, Vol. 34, No. 1-2 Volume 150Issue 1 January 1993Pages 83-86 Metrics PDF download History Published online 1 April 2006 Published in print 1 January 1993