The present study examines the effects of six weather parameters (temperature, wind power, sunlight, precipitation, air pressure, and photoperiod) on mood (positive affect, negative affect, and tiredness). Data were gathered from an online diary study (N = 1,233), linked to weather station data, and analyzed by means of multilevel analysis. Multivariate and univariate analyses enabled distinction between unique and shared effects. The results revealed main effects of temperature, wind power, and sunlight on negative affect. Sunlight had a main effect on tiredness and mediated the effects of precipitation and air pressure on tiredness. In terms of explained variance, however, the average effect of weather on mood was only small, though significant random variation was found across individuals, especially regarding the effect of photoperiod. However, these individual differences in weather sensitivity could not be explained by the Five Factor Model personality traits, gender, or age.