The American Fisheries Society Endangered Species Committee herein provides a list of all crayfishes (families Astacidae and Cambaridae) in the United States and Canada that includes common names; state and provincial distributions; a comprehensive review of the conservation status of all taxa; and references on biology, conservation, and distribution. The list includes 363 native crayfishes, of which 2 (⟨ 1%) taxa are listed as Endangered, Possibly Extinct, 66 (18.2%) are Endangered, 52 (14.3%) are Threatened, 54 (14–9%) are Vulnerable, and 189 (52.1%) are Currently Stable. Limited natural range continues to be the primary factor responsible for the noted imperilment of crayfishes; other threats include the introduction of nonindigenous crayfishes and habitat alteration. While progress has been made in recognizing the plight of crayfishes, much work is still needed.