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Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

Authors
Meng Yuan,Deli Huang
Chang-Chun D. Lee,Nicholas C. Wu,Abigail M. Jackson,Xueyong Zhu,Hejun Liu,Linghang Peng,Marit J. van Gils,Rogier W. Sanders,Dennis R. Burton,S. Momsen Reincke,Harald Prüss,Jakob Kreye,David Nemazee,Andrew B. Ward,Ian A. Wilson,Chang-Chun Lee,Nicholas Wu,Abigail Jackson,Marit Gils,Rogier Sanders,Dennis Burton,S. Reincke,Harald Prüß,Andrew Ward
+24 authors
,Ian Wilson
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May 21, 2021
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Abstract

Defenses against SARS-CoV-2 variants Our key defense against the COVID-19 pandemic is neutralizing antibodies against the SARS-CoV-2 virus elicited by natural infection or vaccination. Recent emerging viral variants have raised concern because of their potential to escape antibody neutralization. Wang et al . identified four antibodies from early-outbreak convalescent donors that are potent against 23 variants, including variants of concern, and characterized their binding to the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Yuan et al . examined the impact of emerging mutations in the receptor-binding domain of the spike protein on binding to the host receptor ACE2 and to a range of antibodies. These studies may be helpful for developing more broadly effective vaccines and therapeutic antibodies. —VV

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