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Caloric restriction prevents age-related deficits in LTP and in NMDA receptor expression

Authors
Luise Lago,Roz Shafran
Iskender Engin Ture,Jose J Gaforio,Michel BONNEAU,Teresa A. Centeno,Basilio Baseia,Graham Le Gros,Antonio Benito Fuertes,Sirkka-Liisa Jamsa-Jounela,Maribel Beltrán,Horacio Alves,Masabumi Minami,J Scott Yaruss,Christine Klaas,Anna Maria Maccioni,Bruno Marino,Paolo Reggiani,Magda Guilera,Peter K.N. Yu,Milena Villarini,Ana Garcia,Rainer Viktor Haberberger,Pavel Povinec,Nicholas Cook,Joseph DENTZER,Ana Otero,Renata Reisfeld,Cameron Dougall Campbell,miklos vasarhelyi,Christopher Talbot,Jürgen Sandkühler,richard Novick,Itzhak Roditi,Franck THIBAULT,Gregory Cutter,Daigee Shaw,Peter Højrup,Rosa Carballo,Vitalii Ivanov,Harry Whitlow,Robert Armon,Yasuyuki Fujiwara,Robert Jacobson,Paul Worsfold,Nicoletta DESIDERI,Luis Fermin Capitan Vallvey,Vincenzo Crunelli,Corrado Lodovico Galli,Kazuhiko Misawa,Stéphen Manon,Mircea Vinatoru,Timo Teräsvirta,Jolanta Sokołowska,Mats Halvarsson,Holger Busse,Nobuhiro Kuriyama,Klaus H. Hoffmann,Laurent Latxague,David Kilcrease,Giacomo MUZI,Robert Phillips,IOLANDA OSVATH,Elliott Pearl,Hanna Wickstrom,Katrina Dlugosch,Nathan Patmore,Peter Rogowsky,Pupa Gilbert,David Banks,Eugenio Velasco-Ortega,James Suliburk,András Csillag,Luc Defreyne,Massimiliano Migliori,David Horák,Paul Hagan,Zdeněk Dostál,Colin Fishwick,Francis Chaouloff,Evandro Moraes da Gama,Ieso Miranda Castro,José Luis PIZARRO SANZ,David Towey,Constantinos Christou,Jose Rabi,Ricci Pak Hong Yue,Jan Konrad Siwicki,Frederick Kaefer,Miguel Cordero,Antony St-Jacques,FRANTZISKO XABIER ALBIZURI IRIGOYEN,Maria Nazare Pinheiro,Usha Mohan,Fabio Anselmi,David Miranda,Olga Lebedeva,Beatriz Praena,Gerben Straatsma,Thomas Huettemann,Cruz Ángel Echevarría,Shimin Wang,Anna Wilson,Nuria Boluda Botella,Jozsef Balint,Prof. Jagadeesh Bhattarai,Maxim Sokolov,Stefan Stein,David Croson,Nicoline Schiess,Lena Gumaelius,Nobuhiro ISHIHARA,Sergey Gulin,VALENTINA BRUNELLA,John Boyle,Natalia Sherwood,Juan Francisco Villarreal-Chiu,Lukas Graf,JANINA KAMINSKA,Sandra Buján,Jan Snel,Andrew Mannes,Sergey Yampolskii,Hanae Nozaki,Maurizio Fadda,Bernardus de Jong,Junichi Nishijo,André van Maurik,Siah Hwee Ang,Drew Simms,Jorge Verdín,Florian Schuberth,Sergiy Sydorenko,Michelle Martinez,Jan Mangerud,Kensuke Yanagi,Wataru Kanda,Matija Stevanovic,Magdalena Sikora,Alexander Vidybida,Rafael Antonio Vargas Vargas,Parker Mills,Jiwoon Kwon,Petr Maca,Yang Deng,Ian Livingstone,Joaquín V. 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May 1, 2000
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Abstract

A major focus of aging research has been the search for treatments that will prevent or ameliorate the memory deficits associated with aging. One paradigm, lifelong caloric restriction, has been reported to reduce some of the effects of aging. In the current report, we examined the effects of this treatment on age-related deficits in LTP, a putative cellular building block for memory formation. We report here that lifelong caloric restriction completely prevents the age-related deficit in LTP. In addition, we report that there is a dramatic decrease in the expression of the NMDA receptor subunit NR1 in aged rats and this age-related defect is also prevented by caloric restriction. These data provide a molecular and cellular mechanism by which life long caloric restriction may ameliorate some of the cognitive deficits associated with the aging process.

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