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A reservoir of stem-like CD8 + T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response

Biochemistry
Oncology
Immunology
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Authors
Kelli A. Connolly,Manik Kuchroo
Aarthi Venkat,Achia Khatun,Jiawei Wang,Ivana William,Noah I. Hornick,Brittany L. Fitzgerald,Martina Damo,Moujtaba Y. Kasmani,Can Cui,Eric Fagerberg,Isabel Monroy,Amanda Hutchins,Julie F. Cheung,Gena G. Foster,Dylan L. Mariuzza,Mursal Nader,Hongyu Zhao,Weiguo Cui,Smita Krishnaswamy,Nikhil S. Joshi,Kelli Connolly,Noah Hornick,Brittany Fitzgerald,Moujtaba Kasmani,Julie Cheung,Gena Foster,Dylan Mariuzza
+27 authors
,Nikhil Joshi
Journal
Science Immunology
Published
Sep 2, 2021
DOI
10.1126/sciimmunol.abg7836
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Abstract

Tumor-specific CD8 + T cells in stable tumor-draining lymph node reservoir are clonally and developmentally related to those in tumors.

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