Paper
Document
Download
Flag content
1

Dairy consumption and risks of total and site-specific cancers in Chinese adults: an 11-year prospective study of 0.5 million people

Authors
Maria Kakkoura,Huaidong Du
Yu Guo,Canqing Yu,Ling Yang,Pei Pei,Yiping Chen,Sam Sansome,Wing Chan,Xiaoming Yang,Lei Fan,Jun Lv,Junshi Chen,Liming Li,Timothy Key,Zhengming Chen,Robert Clarke,Rory Collins,Chen Wang,Richárd Pető,Robin Walters,Daniel Avery,Derrick Bennett,Ruth Boxall,Ka Chan,Yu‐Mei Chang,Johnathan Clarke,Zammy Fairhurst-Hunter,Hannah Fry,Simon Gilbert,Alex Hacker,Mike Hill,Michael Holmes,Pek Im,Andri Iona,Christiana Kartsonaki,Rene Kerosi,Kuang Lin,Mohsen Mazidi,Iona Millwood,Qunhua Nie,Alfred Pozarickij,Paul Ryder,Saredo Said,Dan Schmidt,Paul Sherliker,Rajani Sohoni,Becky Stevens,Iain Turnbull,Lin Wang,Neil Wright,Pang Yao,Xiao Han,Can Hou,Qingmei Xia,Chao Liu,Naying Chen,Duo Liu,Zhenzhu Tang,Ningyu Chen,Qilian Jiang,Jian Lan,Mingqiang Li,Yun Liu,Fanwen Meng,Jia Meng,Rong Pan,Yulu Qin,Píng Wang,Sisi Wang,Liuping Wei,Liyuan Zhou,Caixia Dong,Pengfei Ge,Xiaolan Ren,Zhongxiao Li,Enke Mao,Tao Wang,Hui Zhang,Xi Zhang,Jinyan Chen,Xiaoyi Hu,Xiaohuan Wang,Zhendong Guo,Huimei Li,Yilei Li,Min Wang,Shukuan Wu,Shichun Yan,Mingyuan Zou,Xue Zhou,Ziyan Guo,Qi Kang,Yanjie Li,Bo Yu,Qinai Xu,Liang Chang,Feng Shi,Ding Zhang,Gang Zhou,Yulian Gao,Tianyou He,Pan He,Chen Hu,Huarong Sun,Xukui Zhang,Biyun Chen,Zhongxi Fu,Yuelong Huang,Huilin Liu,Qi Xu,Yin Li,Huajun Long,Xin Xu,Hao Zhang,Libo Zhang,Jian Su,Ran Tao,Ming Wu,Jie Yang,Jinyi Zhou,Yonglin Zhou,Yihe Hu,Yujie Hua,Jianrong Liu,Jingchao Liu,Yan Liu,Liangcai Ma,Aiyu Tang,Jun Zhang,Liang Cheng,Ranran Du,Ruqin Gao,Feifei Li,Shanpeng Li,Yongmei Liu,Na Feng,Zengchang Pang,Xiaohui Sun,Xiaocao Tian,Shaojie Wang,Yaoming Zhai,Hua Zhang,Wei Hou,Silu Lv,Junzheng Wang,Xiaofang Chen,Xianping Wu,Ningmei Zhang,Weiwei Zhou,Jianguo Li,Jiaqiu Liu,Guojin Luo,Qiang Sun,Xunfu Zhong,Weiwei Gong,Ruying Hu,Hao Wang,Wei Meng,Min Yu,Lingli Chen,Qijun Gu,Dongxia Pan,Chunmei Wang,Kaixu Xie
+163 authors
,Xiaoyi Zhang
Published
May 6, 2022
Show more
Save
TipTip
Document
Download
Flag content
1
TipTip
Save
Document
Download
Flag content

Abstract

Previous studies of primarily Western populations have reported contrasting associations of dairy consumption with certain cancers, including a positive association with prostate cancer and inverse associations with colorectal and premenopausal breast cancers. However, there are limited data from China where cancer rates and levels of dairy consumption differ importantly from those in Western populations.The prospective China Kadoorie Biobank study recruited ~0.5 million adults from ten diverse (five urban, five rural) areas across China during 2004-2008. Consumption frequency of major food groups, including dairy products, was collected at baseline and subsequent resurveys, using a validated interviewer-administered laptop-based food frequency questionnaire. To quantify the linear association of dairy intake and cancer risk and to account for regression dilution bias, the mean usual consumption amount for each baseline group was estimated via combining the consumption level at both baseline and the second resurvey. During a mean follow-up of 10.8 (SD 2.0) years, 29,277 incident cancer cases were recorded among the 510,146 participants who were free of cancer at baseline. Cox regression analyses for incident cancers associated with usual dairy intake were stratified by age-at-risk, sex and region and adjusted for cancer family history, education, income, alcohol intake, smoking, physical activity, soy and fresh fruit intake, and body mass index.Overall, 20.4% of participants reported consuming dairy products (mainly milk) regularly (i.e. ≥1 day/week), with the estimated mean consumption of 80.8 g/day among regular consumers and of 37.9 g/day among all participants. There were significant positive associations of dairy consumption with risks of total and certain site-specific cancers, with adjusted HRs per 50 g/day usual consumption being 1.07 (95% CI 1.04-1.10), 1.12 (1.02-1.22), 1.19 (1.01-1.41) and 1.17 (1.07-1.29) for total cancer, liver cancer (n = 3191), female breast cancer (n = 2582) and lymphoma (n=915), respectively. However, the association with lymphoma was not statistically significant after correcting for multiple testing. No significant associations were observed for colorectal cancer (n = 3350, 1.08 [1.00-1.17]) or other site-specific cancers.Among Chinese adults who had relatively lower dairy consumption than Western populations, higher dairy intake was associated with higher risks of liver cancer, female breast cancer and, possibly, lymphoma.

Paper PDF

Empty State
This PDF hasn't been uploaded yet.
Do not upload any copyrighted content to the site, only open-access content.
or