Paper
Document
Submit new version
Download
Flag content
2

A stem cell aging framework, from mechanisms to interventions

Published
Oct 1, 2022
Show more
Save
TipTip
Document
Submit new version
Download
Flag content
2
TipTip
Save
Document
Submit new version
Download
Flag content

Abstract

Stem cells play central roles in tissue development, homeostasis, and regeneration. Decades of scientific research have uncovered processes of stem cell decline in tissue and organismal aging, and more recently, pioneering technologies permit the dissection of its underlying mechanisms and inform therapeutic development for aging and aging-associated disorders. In this review, we elucidate aging-related features across different somatic stem cell types, with a specific focus on epigenetic changes, loss of protein homeostasis, and systemic influencing factors, including chronic inflammation, circadian rhythm dysregulation, and metabolic disorder. Our survey of organismal stem cell aging summarizes its underlying biological implications, points to potential biomarkers of stem cell aging, and discusses stem cell-based therapeutic strategies with the potential for promoting healthy aging and combating aging and age-related diseases.

Paper PDF

Empty State
This PDF hasn't been uploaded yet.
Do not upload any copyrighted content to the site, only open-access content.
or