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Ventral hippocampus neurons encode meal-related memory

Authors
Lea Decarie-Spain,Cindy Gu
Logan Tierno Lauer,Keshav S Subramanian,Samar N Chehimi,Alicia E Kao,Iris Deng,Alexander G Bashaw,Molly E Klug,Ashyah Hewage Galbokke,Kristen N Donohue,Mingxin Yang,Guillaume de Lartigue,Kevin P Myers,Richard C Crist,Benjamin C. Reiner,Matthew R Hayes,Scott Kanoski,Léa Décarie-Spain,Logan Lauer,Keshav Subramanian,Samar Chehimi,Alicia Kao,Alexander Bashaw,Molly Klug,Ashyah Galbokke,Kristen Donohue,Guillaume Lartigue,Kevin Myers,Richard Crist,Benjamin Reiner,Matthew Hayes
+30 authors
,Minghong Yang
Published
Jan 1, 2023
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Abstract

The ability to encode and retrieve meal-related information is critical to efficiently guide energy acquisition and consumption, yet the underlying neural processes remain elusive. Here we reveal that ventral hippocampus (HPCv) neuronal activity dynamically elevates during meal consumption and this response is highly predictive of subsequent performance in a foraging-related spatial memory task. Targeted recombination-mediated ablation of HPCv meal-responsive neurons impairs foraging-related spatial memory without influencing food motivation, anxiety-like behavior, or escape-mediated spatial memory. These HPCv meal-responsive neurons project to the lateral hypothalamic area (LHA) and single-nucleus RNA sequencing and in situ hybridization analyses indicate they are enriched in serotonin 2a receptors (5HT2aR). Either chemogenetic silencing of HPCv-to-LHA projections or intra-HPCv 5HT2aR antagonist yielded foraging-related spatial memory deficits, as well as alterations in caloric intake and the temporal sequence of spontaneous meal consumption. Collective results identify a population of HPCv neurons that dynamically respond to eating to encode meal-related memories.

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