Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has proven to be a promiscuous virus, capable of infecting a variety of different animal species, but much work remains in determining the susceptibility of common wildlife species to the virus. Here, we demonstrate that following experimental inoculation with SARS-CoV-2, red fox ( Vulpes vulpes ) become infected and can shed virus in oral and respiratory secretions. Conversely, experimentally challenged coyotes ( Canis latrans ) did not become infected or shed virus. Our results add red fox to the animal species known to be susceptible to SARS-CoV-2 and suggest that they may contribute to continued maintenance and transmission of the virus. Article Summary Line Experimental infection of red fox ( Vulpes vulpes ) and coyotes ( Canis latrans ) with SARS-CoV-2 revealed that red fox are susceptible to infection and can shed virus, while coyotes do not become infected.

Susceptibility of wild canids to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)