Distinct feedforward and feedback pathways for cell-type specific attention effects

Abstract

Abstract Spatial attention selectively enhances neural responses to visual stimuli. There are two long-standing hypotheses about how top-down feedback enhances sensory responses in areas like V4: First, by amplifying V1-to-V4 feedforward communication via 30-80Hz gamma-coherence. Second, via top-down feedback to V4 supra- and infra-granular layers. To test these hypotheses, we recorded distinct cell-types across macaque V1 and V4 layers. Attention increased both V1-V4 gamma-coherence and V4 spike-rates, yet with distinct laminar and cell-type profiles. Surprisingly, V1 gamma did not engage V4 excitatory neurons, but only Layer-4 fast-spiking interneurons. Similar observations were made in mouse visual-cortex, where feedforward gamma-influences preferentially recruit optogenetically-tagged PV+ and narrowwaveform SSt+ interneurons. By contrast, attention enhanced V4 spike-rates in both excitatory neurons and fast-spiking interneurons, with the strongest and earliest modulation in Layer-2/3, consistent with a feedback influence. These findings reveal distinct feedforward and feedback pathways for the attentional modulation of inter-areal coherence and spike rates, respectively.