Abstract Purpose To test the feasibility of simultaneous steady-state pattern electroretinogram (PERG) and intraocular pressure (IOP) measurements with an IOP sensor and to test a model for IOP manipulation during lateral decubitus positioning (LDP) and its impact on the PERG. Design A prospective, observational study. Methods 15 healthy controls and 15 treated glaucoma patients participated in the study. 8 patients had an intraocular IOP sensor (eyemate-IO ® , Implandata Ophthalmic Products GmbH) in the right eye (GLA IMP ) and 7 had no sensor and with glaucoma in the left eye. (1) We tested the feasibility of simultaneous IOP and PERG recordings by comparing PERGs with and without simultaneous IOP-read out in GLA IMP . (2) All participants were positioned in the following order: sitting1 (S1), right LDP (LD R ), sitting2 (S2), left LDP (LD L ) and sitting3 (S3). For each position, PERG amplitudes and IOP were determined with rebound tonometry (Icare® TA01i) in all participants without the IOP sensor. Results Electromagnetic intrusions of IOP sensor readout onto steady-state PERG-recordings had, due to different frequency ranges, no relevant effect on PERG amplitudes. IOP and PERG measures were affected by LDP, e.g., IOP was increased during LD R vs S1 in the lower eyes of GLA IMP and controls (P &lt; 0.001 and P &lt; 0.05, respectively) and PERG amplitude was decreased (P &lt; 0.05 and P &lt; 0.01, respectively). Conclusions During LDP, IOP and PERG measurements changed more in the lower eye. IOP changes induced by LDP may be a model for studying the interaction of IOP and ganglion cell function.

Interaction of intraocular pressure and ganglion cell function in open angle glaucoma