Abstract Precision medicine and the investigation of brain-behavior associations require biomarkers that are stable (low intraindividual variability) and unique (high interindividual variability) at the same time, hence calling them “fingerprints”. The functional connectome (FC) has good “fingerprint properties”, as individuals can be accurately identified in a database based on their FC. Importantly, research has shown lower intraindividual variability of more localized measures of brain function such as regional homogeneity (ReHo) and (fractional) amplitude of low-frequency fluctuations ((f)ALFF), compared to the FC. Here, with fMRI data from two publicly available datasets we demonstrate that individuals can be identified with near-perfect accuracies using local functional fingerprints, and especially the regional homogeneity (ReHo) fingerprint. Further analyses reveal that the dorsal attention network contributes most to the individual “uniqueness” of the ReHo fingerprint. Moreover, using a machine-learning setup, we show that the small intraindividual ReHo fingerprint variability across sessions is meaningful for explaining individual-level intelligence. Last, using two other publicly available datasets, clinical applicability is shown with high fingerprint accuracies and a significant correlation between fingerprint stability and intelligence in individuals with schizophrenia. Altogether, our findings suggest that the ReHo fingerprint is a good candidate for further exploration of applicability in precision medicine.

Spatially localized fMRI metrics as predictive and highly distinct state-independent fingerprints