Scalable power analysis and effect size exploration of microbiome community differences with Evident

Abstract

Abstract Differentiating microbial communities among samples is a major objective in biomedicine. Quantifying the effect size of these differences allows researchers to understand the factors most associated with communities and to optimize the design and clinical resources required to address particular research questions. Here, we present Evident, a package for effect size calculations and power analysis on microbiome data and show that Evident scales to large datasets with numerous metadata covariates.