Paper
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Long non-coding RNA RGMB-AS1 as a novel modulator of Bone Morphogenetic Protein Receptor 2 signaling in pulmonary arterial hypertension
Authors
Khadem Ali,Yu Liu
Liang Zhao,Joseph Wu,Vinicio Perez,Christopher Rhodes,Aiqin Cao,Martin Wilkins,Mark Nicolls,Edda Spiekerkoetter,Md Ali
+9 authors
,Vinicio PérezPublished
Aug 27, 2022
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Abstract
Abstract This study shows that the long non-coding RNA RGMB-AS1 is upregulated in the blood and pulmonary vascular cells of PAH patient and that it regulates BMPR2 signaling. Inhibiting RGMB-AS1 increases BMPR2 signaling and improves pulmonary vascular cell function.
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