AIM: To investigate a potential protective role of the kinin B2 receptor in a glycerol-induced rhabdomyolysis mouse model. METHODS:We separated 28 C57Bl/6 male mice into 4 groups: untreated WT animals, untreated B2 knockout mice, glycerol-treated WT and glycerol-treated B2 knockout mice.Glycerol-treated animals received one intramuscular injections of glycerol solution (50% v/v, 7 mL/kg).After 48 h, urine and blood samples were collected to measure creatinine and urea levels.Additionally, kidney samples were extracted for histological evaluation, and the mRNA expression levels of kinin B1 and B2 receptors and inflammatory mediators were measured by real-time polymerase chain reaction. RESULTS:Serum creatinine and urea levels showed differences between untreated wild-type and glycerol-CONCLUSION: We conclude that the kinin B2 receptor

Kinin B2 receptor does not exert renoprotective effects on mice with glycerol-induced rhabdomyolysis