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Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice
Authors
Ashleigh King,Pia Reichl
Jean S Metson,Robert Parker,Daniella Munro,Catarina Oliveira,Jordan R Becker,Daniel Biggs,Chris Preece,Benjamin Davies,J. Ross Chapman,Jean Metson,Jordan Becker
+11 authors
,J. ChapmanPublished
Dec 21, 2023
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Abstract
53BP1 regulates DNA end-joining in lymphocytes, diversifying immune antigen receptors. This involves nucleosome-bound 53BP1 at DNA double-stranded breaks (DSBs) recruiting RIF1 and shieldin, a poorly understood DNA-binding complex. The 53BP1-RIF1-shieldin axis is pathological in
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