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Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

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Edward Skolnik,Srećko Valić
Juan José Hernández-Rey,Ivano Lippi,Agnieszka Zalewska,Javier Berdugo,Augustin Kasser,Fernando Barao,Helen Miliou,Michael Bradnam,Maurizio Fauri,Scott Linn,Fiorella Marcheselli,Jose Rodriguez-Alvarez,Rina Recchioni,Quentin Stout,Olivier Monga,Fujio Murakami,David Njus,Yolanda Jimenez-Teja,Terrence Piva,David Henderson,David Mayerhoff,Istvan Csige,Nicolas THOUVENY,Jacek Najda,Waldemar Turski,Ewa Lipczynska-Kochany,Augusto Neiva,Itzhak Roditi,Maria Mazurkiewicz-Bełdzińska,Vicente Gaitan Alcalde,Lucie Linssen,Sue Kilcoyne,Mercedes Fernández-Alonso,Juan Zuniga,Ubaldo Bottigli,Siegfried Schreiber,Miriam Peñalba,Ole Ellegaard,Boris Altoiz,Julio Lozano Bahilo,Max Baker,Susan J Ward,FERNANDO AZORIN,Juha Savola,Steven Kehl,Vadim Kaplunovsky,Carlos L. Pando L.,gerhard welsch,Gilles Querat,Gilles Audoly,Gregory Cutter,Thomas Castonguay,alireza beheshti,Joan Solà,Enrico Maglione,MARCO ERCOLE VANONI,Isaa Fakhr,Forough Ghasemi Naghdi,James Bates,Henri Godfrin,Bruno Maraviglia,Marco Falasca,Mark Gaze,Louis Matzel,Vladimir Kostyuk,Michael Strauss,Diego Peñaloza,Fredrik Bergholm,Haruyuki Kamiya,SACHIN PANDEY,Giuseppe Malizia,Peter Paulini,Joana Almeida,Tim Smith,Andrey Stepkin,Valery Yanovskiy,adriana arena,SUET LIN CHIA,Catherine Schmidt-Mutter,Krzysztof Jakubiak,Andreas Eckert,Aronne CRAGLIETTO,Anna Maria Murdaca,Stella Brassesco,Inge Unfried,Alexander Krasulin,Alexandra Vallet,Josefina Hernandez-Nistal,Francis Emile Asuquo,Miroslaw Bocian,Thao Duy Nguyen,Brahim KEBABI,Rajiv Kumar,Philip Jackson,Bunyo Hatsukade,Christofer Bäcklin,Paolo Palazzi,Corrin Wallis,Leonidas Mindrinos,Francesco Fidecaro,Joenel Alcantara,Bahar Meshginqalam,Gabriel Juarez,Ansuman Lahiri,Pierre Glynn,Paolo Walter Cattaneo,Monika Eisenbardt,Michelle French,Wojciech Kaczmarek,Zhizheng Pan,Åsa Källström,Nadine Mofaddel,Yoko Honda,Justyna Urban,Kenneth Chiacchia,Andrzej Szkaradkiewicz,Elżbieta Bilska-Wodecka,Reece Hart,John O'Meara,Brian Ellwood Jones,Mariangiola Dezani,Manuel Suero Suñe,Paul Vanden Bout,Robin Burgess-Limerick,Gary Hunter,peng xiu,Martin Lind,Sergey Traytak,Manuel Delfino,Jerzy Topp,Anne PHILIPPE,Luisa DP Rona,Laurence ROMANA,Dennis Muhanguzi,Marian Dygo,Jesus M. 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Josh Huang,Kiyotomo Kawagoe,Mauro MORETTI,Andrzej Betlej,Sylvie DELANIAN,Roberto Zamboni,Manuel Rodríguez Díaz,R. Fischer,A. Drepps,Axel Ullrich,Eve Lowenstein,Nina Zheleznova,Ben Margolis,Moosa Mohammadi
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,Joseph Schlessinger
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Apr 1, 1991
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Abstract

A novel method has been developed to allow cloning of protein targets for receptors with tyrosine kinase activity. By utilizing the carboxy-terminal tail of EGF receptor (EGFR) as a probe to screen lambda gt11 expression libraries, several EGFR-binding proteins have been cloned; two have been analyzed and contain unique SH2 and SH3 domains. One gene (GRB-1) has been fully sequenced, is expressed in various tissues and cell lines, and has a molecular mass of 85 kd. Interestingly, GRB-1 encodes the human counterpart of the PI3 kinase-associated protein p85. Advantages of this technique include the ease of cloning tyrosine kinase receptor targets present at low levels and the ability to identify proteins that are related in their capacity to bind activated receptors but contain no significant DNA sequence homology. This method, termed CORT (for cloning of receptor targets), offers a general approach for the identification and cloning of various receptor targets.

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