Single-cell-resolved interspecies comparison shows a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19

Abstract

Humans and hamsters share a common inflammatory response to SARS-CoV-2 d Disease severity correlates with early innate effector cell-type response d Diffusion-based analyses dissect neutrophil and endothelial cell responses during infection d Differences in cell-type responses lead to either reversible or terminal endothelial damage