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Discovery of GS-7682, a Novel 4′-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys
Authors
Dustin Siegel,Hon Hui
Jared Pitts,Meghan Vermillion,Kazuya Ishida,Davin Rautiola,Michael Keeney,Hammad Irshad,Qian Zhang,Kwon Chun,Gregory Chin,Bindu Goyal,Edward Doerffler,Hai Yang,Michael Clarke,Chris Palmiotti,Arya Vijjapurapu,Nicholas Riola,Kirsten Stray,Eisuke Murakami,Bin Ma,Ting Wang,Xiaofeng Zhao,Yili Xu,Gary Lee,Bruno Marchand,Minji Seung,A. Nayak,Adrian Tomkinson,Nani Kadrichu,S Ellis,Ona Barauskas,Joy Feng,Jason Perry,Michel Perron,John Bilello,Philip Kuehl,Raju Subramanian,Tomáš Cihlář,Richard Mackman
+38 authors
,S. EllisPublished
Jul 17, 2024
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Abstract
Acute respiratory viral infections, such as pneumovirus and respiratory picornavirus infections, exacerbate disease in COPD and asthma patients. A research program targeting respiratory syncytial virus (RSV) led to the discovery of GS-7682 (
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