Discovery of GS-7682, a Novel 4′-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys

Authors

Dustin Siegel

Published

July 17, 2024

Abstract

Acute respiratory viral infections, such as pneumovirus and respiratory picornavirus infections, exacerbate disease in COPD and asthma patients. A research program targeting respiratory syncytial virus (RSV) led to the discovery of GS-7682 (

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Journal

Journal of Medicinal Chemistry

Topics

DOI

10.1021/acs.jmedchem.4c00899

Discovery of GS-7682, a Novel 4′-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys

Authors

Dustin Siegel

Published

July 17, 2024

Abstract

Supporters

Support the authors with ResearchCoin

Journal

Journal of Medicinal Chemistry

Topics

DOI

10.1021/acs.jmedchem.4c00899

Paper

Paper

Paper

Paper

Discovery of GS-7682, a Novel 4′-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys

Abstract

Supporters

Journal

Topics

DOI

Discovery of GS-7682, a Novel 4′-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys

Abstract

Supporters

Journal

Topics

DOI