Abstract

Ventilation measurements using signal differences between expiratory and inspiratory respiration states gained popularity as a biomarker for ventilation abnormalities. One method, which incorpartes such measurements is Phase-resolved functional lung imaging (PREFUL). A further classification of abnormalities such as emphysema and air-trapping beyond the current gas-exchange measurement is desirable. Therefore a MR adaption of CT’s parametric-response mapping (CTPRM) method is proposed as an additional post-processing method for PREFUL. The analysis of 34 patients with chronic obstructive pulmonary disease (COPD), shows that there is a high regional (Overlap normal 91%) and total lung concordance (r>0.86) for the proposed method PREFULPRM and CTPRM.