Abstract

The effectiveness and prognosis of thoracoscopic lobectomy in sennior individuals with early-stage cancer were evaluated by assessing the value of microRNAs (miR)-21 and miR-141. A total of 116 sennior individuals with early-stage cancer were divided into two cohorts based on the surgical effect: the observation cohort (effective) and the control cohort (ineffective). Moreover, 80 healthy individuals who underwent medical examination were selected as the comparison cohort B. The levels of serum miR-141serum miR-21 and were assessed in all participants. The comparison revealed that the highest levels of these two serum biomarkers were observed in control cohort A, followed by the observation cohort, and the lowest levels were found in control cohort B (P<0.05). The receiver operating characteristic curve (ROC) analysis showed that the area under the curve for individual assessment of miR-141 and miR-21 in predicting efficacy and prognosis were 0.838 and 0.740, respectively. The sensitivity and specificity for miR-21 were 85.3% and 76.2%, respectively, while for miR-141, they were 53.7% and 85.1%, respectively. These findings suggest that serum miR-21 and serum miR-141 are closely associated with postoperative efficacy and prognosis in individuals with early-stage cancer. Both miR-141 and miR-21 can serve as biomarkers for evaluating effectiveness and prognosis.