Abstract Background Food protein‐induced enterocolitis syndrome (FPIES) is a non–IgE‐mediated food allergy. In the last few years, after the publication of the consensus guidelines, with refined diagnostic criteria and improved awareness, FPIES is diagnosed with increased frequency. However, despite having a background of immune dysregulation, this complication has just been described once in the posttransplant setting, in an adult patient. To the best of our knowledge, there are no reports of pediatric patients developing FPIES after a hematopoietic stem cell transplant (HCT). Methods Retrospective review of a pediatric patient who developed severe FPIEs after a HCT. Results In this case report, the clinical presentation and diagnosis challenges of a pediatric patient who developed severe FPIES after HCT are described. The patient developed severe vomiting, diarrhea, lethargy, and shock and required admission to the pediatric intensive care unit in three occasions before the diagnosis was made. Conclusions To the best of our knowledge, this is the first report of severe FPIES post‐HCT in a pediatric patient. Physicians who are looking after pediatric patients in the post‐HCT setting need to be aware of this possibility and include this entity in the differential diagnosis in order to reduce its associated morbidity.

Severe Food Protein‐Induced Enterocolitis Syndrome After Hematopoietic Stem Cell Transplantation: Pediatric Case Report