Trivalent phosphine catalysis is mostly utilized to activate the carbon‐carbon multiple bonds to form carbanion intermediate species and highly sensitive to certain variables. Random manual multi‐variables are critical for understanding the batch disabled regeneration of trivalent phosphine chemistry. We need the artificial intelligence‐based system which can change the variable based on previously conducted failed experiment. Herein, we report an auto‐optimized electro‐micro‐flow reactor platform for the in‐situ reduction of stable P(V) oxide to sensitive P(III) and further utilized for Corey‐Fuchs reaction.

Auto‐Optimized Electro‐Flow Reactor Platform for the in‐situ Reduction of P(V) Oxide to P(III) and Their Application