Meta-analysis of genetic association with diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing

R Sims,JC Bis,AC Naj,A Boland,M Vronskaya,SJ Lee,A Amlie-Wolf,C Bellenguez,A Frizatti,V Chouraki,ER Martin,K Sleegers,N Badarinarayan,J Jakobsdottir,KL Hamilton-Nelson,R Aloso,R Raybould,Y. Chen,AB Kuzma,M Hiltunen,T Morgan,S Ahmad,BN Vardarajan,J Epelbaum,P Hoffmann,M Boada,GW Beecham,JG Garnier,D Harold,AL Fitzpatrick,O Valladares,ML Moutet,A Gerrish,AV Smith,L Qu,D Bacq,N Denning,X Jian,Y. Zhao,MD Zompo,NC Fox,ML Grove,SH Choi,I Mateo,JT Hughes,HH Adams,J Malamon,FS Garcia,Y. Patel,JA Brody,B Dombroski,MCD Naranjo,M Daniilidou,G Eiriksdottir,S Mukherjee,D Wallon,J Uphill,T Aspelund,LB Cantwell,F Garzia,D Galimberti,E Hofer,M Butkiewics,B Fin,E Scarpini,C Sarnowski,W Bush,S Meslage,J Kornhuber,CC White,Y. Song,RC Barber,S Engelborghs,S Pichler,D Voijnovic,PM Adams,R Vandenberghe,M Mayhaus,LA Cupples,MS Albert,PP Deyn,W Gu,JJ Himali,D Beekly,A Squassina,AM Hartmann,A Orellana,D Blacker,E Rodriguez-Rodriguez,S Lovestone,ME Garcia,RS Doody,CM Fernadez,R Sussams,H Lin,TJ Fairchild,YA Benito,C Holmes,H Comic,MP Frosch,H Thonberg,W Maier,G Roschupkin,B Ghetti,V Giedraitis,A Kawalia,S Li,RM Huebinger,L Kilander,S Moebus,I Hernández,MI Kamboh,R Brundin,J Turton,Q Yang,MJ Katz,L Concari,J Lord,AS Beiser,CD Keene,S Helisalmi,I Kloszewska,WA Kukull,AM Koivisto,A Lynch,L Tarraga,EB Larson,A Haapasalo,B Lawlor,TH Mosley,RB Lipton,V Solfrizzi,M Gill,WT Longstreth,TJ Montine,V Frisardi,S Ortega-Cubero,F Rivadeneira,RC Petersen,V Deramecourt,A Ciaramella,E Boerwinkle,EM Reiman,N Fievet,C Caltagirone,JI Rotter,JS Reisch,O Hanon,C Cupidi,A.G. Uitterlinden,DR Royall,C Dufouil,RG Maletta,S Moreno-Grau,M Sano,A Brice,R Cecchetti,P George-Hyslop,K Ritchie,M Tsolaki,DW Tsuang,B Dubois,D Craig,CK Wu,H Soininen,D Avramidou,RL Albin,L Fratiglioni,A Germanou,LG Apostolova,L Keller,M Koutroumani,SE Arnold,F Panza,O Gkatzima,S Asthana,D Hannequin,P Whitehead,CS Atwood,P Caffarra,H Hampel,CT Baldwin,L Lannfelt,DC Rubinsztein,LL Barnes,F Pasquier,L Frölich,S. Barral,B McGuinness,TG Beach,JI Johnston,JT Becker,P Passmore,EH Bigio,JM Schott,TD Bird,JD Warren,BF Boeve,MK Lupton,JD Bowen,P Proitsi,A Boxer,JF Powell,JR Burke,JK Kauwe,JM Burns,M Mancuso,JD Buxbaum,U Bonuccelli,NJ Cairns,A McQuillin,C Cao,G Livingston,CS Carlson,NJ Bass,CM Carlsson,J Hardy,RM Carney,J Bras,MM Carrasquillo,R Guerreiro,M Allen,HC Chui,E. Fisher,DH Cribbs,C Masullo,EA Crocco,C DeCarli,G Bisceglio,M Dick,L Ma,R Duara,NR Graff-Radford,D.A Evans,A Hodges,KM Faber,M Scherer,KB Fallon,M Riemenschneider,DW Fardo,R Heun,MR Farlow,S Ferris,M Leber,TM Foroud,I Heuser,DR Galasko,I Giegling,M Gearing,M Hüll,DH Geschwind,JR Gilbert,J Morris,RC Green,K Mayo,JH Growdon,T Feulner,RL Hamilton,LE Harrell,D Drichel,LS Honig,TD Cushion,MJ Huentelman,P Hollingworth,CM Hulette,BT Hyman,R Marshall,GP Jarvik,A Meggy,E Abner,G Menzies,LW Jin,G Leonenko,G Jun,D Grozeva,A Karydas,G Russo,JA Kaye,R Kim,F Jessen,NW Kowall,B Vellas,JH Kramer,E Vardy,FM LaFerla,KH Jöckel,JJ Lah,M Dichgans,JB Leverenz,D Mann,AI Levey,S Pickering-Brown,AP Lieberman,N Klopp,KL Lunetta,HE Wichmann,CG Lyketsos,K Morgan,DC Marson,K Brown,F Martiniuk,C Medway,DC Mash,MM Nöthen,E Masliah,NM Hooper,WC McCormick,A Daniele,SM McCurry,A Bayer,AN McDavid,J Gallacher,AC McKee,H Bussche,M Mesulam,C Brayne,BL Miller,S Riedel-Heller,CA Miller,JW Miller,A Al-Chalabi,JC Morris,CE Shaw,AJ Myers,J Wiltfang,S O’Bryant,E Coto,JM Olichney,V Alvarez,JE Parisi,AB Singleton,HL Paulson,J Collinge,W Perry,S Mead,E Peskind,M Rosser,A Pierce,N Ryan,WW Poon,B Nacmias,H Potter,S Sorbi,JF Quinn,E Sacchinelli,A Raj,G Spalletta,M Raskind,P Bossù,B Reisberg,R Clarke,C Reitz,AD Smith,JM Ringman,D Warden,ED Roberson,G Wilcock,E Rogaeva,AC Bruni,HJ Rosen,M. Gallo,RN Rosenberg,Y Ben-Shlomo,MA Sager,P Mecocci,AJ Saykin,P Pastor,ML Cuccaro,JM Vance,J.A. Schneider,LS Schneider,WW Seeley,AG Smith,JA Sonnen,S Spina,RA Stern,RH Swerdlow,RE Tanzi,JQ Trojanowski,JC Troncoso,VM Deerlin,LJ Eldik,HV Vinters,JP Vonsattel,S Weintraub,KA Welsh-Bohmer,KC Wilhelmsen,J Williamson,TS Wingo,RL Woltjer,CB Wright,CE Yu,L Yu,Alzheimer (ADGC),The (EADI),Cohorts (CHARGE),Genetic (GERAD/PERADES),PK Crane,DA Bennett,V Boccardi,P.L. Jager,N Warner,OL Lopez,S McDonough,M Ingelsson,P Deloukas,C Cruchaga,C Graff,R Gwilliam,M Fornage,AM Goate,P Sanchez-Juan,PG Kehoe,N Amin,N Ertekin-Taner,C Berr,S Debette,S Love,LJ Launer,SG Younkin,JF Dartigues,C Corcoran,M.A. Ikram,DW Dickson,D Campion,J Tschanz,H Schmidt,H Hakonarson,R Munger,R Schmidt,LA Farrer,C Broeckhoven,MC O’Donovan,AL DeStefano,L Jones,JL Haines,JF Deleuze,MJ Owen,V Gudnason,R Mayeux,V Escott-Price,BM Psaty,A Ruiz,A Ramirez,LS Wang,C.M. Duijn,PA Holmans,S Seshadri,J Williams,P Amouyel,GD Schellenberg,JC Lambert,M.A. Pericak-Vance,B Kunkle,Benjamin Grenier‐Boley,Rebecca Sims,J.C. Bis,A.C. Naj,Anne Boland,Maria Vronskaya,Alexandre Amlie‐Wolf,Céline Bellenguez,Aura Frizatti,Vincent Chouraki,Kristel Sleegers,Nandini Badarinarayan,Jóhanna Jakobsdóttir,K.L. Hamilton‐Nelson,Rachel Raybould,Y Chen,Mikko Hiltunen,Taniesha Morgan,Shahzad Ahmad,Jacques Epelbaum,Per Hoffmann,Merçé Boada,G Beecham,J. Garnier,Denise Harold,A Fitzpatrick,Otto Valladares,Amy Gerrish,A.V. Smith,Liming Qu,Delphine Bacq,Nicola Denning,Xueqiu Jian,Yi Zhao,Nick Fox,Sung‐Woon Choi,Ignacio Mateo,J. Hughes,John Malamon,Yogen Patel,J. Brody,Beth Dombroski,M.C.D. Naranjo,Makrina Daniilidou,Guðný Eiríksdóttir,Shubhabrata Mukherjee,David Wallon,James Uphill,Thor Aspelund,L.B. Cantwell,Fabienne Garzia,Daniela Galimberti,Edith Hofer,Bertrand Fin,Elio Scarpini,Chloé Sarnowski,William Bush,Stéphane Meslage,Johannes Kornhuber,Yeunjoo Song,Sebastiaan Engelborghs,Sabrina Pichler,Dina Voijnovic,Rik Vandenberghe,Manuel Mayhaus,L. Cupples,Albert Tran,Wei Gu,Duane Beekly,Alessio Squassina,Arndt Hartmann,Adela Orellana,Deborah Blacker,Eloy Rodríguez‐Rodríguez,Simon Lovestone,M. Garcia,R.S. Doody,C.M. Fernadez,Rebecca Sussams,Honghuang Lin,Y.A. Benito,Clive Holmes,C. H.,Frosch Mp,Håkan Thonberg,Wolfgang Maier,G. Roschupkin,Bernardino Ghetti,Vilmantas Giedraitis,Amit Kawalia,Lena Kilander,Susanne Moebus,Isabel Hernández,M. Kamboh,RoseMarie Brundin,James Turton,Qiong Yang,Letizia Concari,Jenny Lord,Alexa Beiser,C. Keene,Seppo Helisalmi,Iwona Kłoszewska,Aoibhinn Lynch,Lluís Tárraga,Larson Eb,Annakaisa Haapasalo,Brian Lawlor,Vincenzo Solfrizzi,Michael Gill,W. Longstreth,Vincenza Frisardi,Sara Ortega‐Cubero,Fernando Rivadeneira,R. Petersen,Vincent Deramecourt,Antonio Ciaramella,Eric Boerwinkle,Reiman Em,Nathalie Fiévet,Carlo Caltagirone,Olivier Hanon,Chiara Cupidi,AG Uitterlinden,Carole Dufouil,R Maletta,Sonia Moreno‐Grau,Mary Sano,Alexis Brice,Roberta Cecchetti,Peter George‐Hyslop,Karen Ritchie,Magda Tsolaki,Bruno Dubois,David Craig,Hilkka Soininen,Despoina Avramidou,Laura Fratiglioni,Antonia Germanou,L.G. Apostolova,Lina Keller,Maria Koutroumani,Francesco Panza,Olymbia Gkatzima,Sanjay Asthana,Didier Hannequin,Patrice Whitehead,Paolo Caffarra,Harald Hampel,Lars Lannfelt,D.C. Rubinsztein,Florence Pasquier,Lutz Frölich,Sandra Barral,Bernadette McGuinness,J.O. Johnston,J. Becker,Peter Passmore,Jonathan Schott,Jason Warren,Petroula Proitsi,Adam Boxer,Joseph Powell,J. Burke,Michelangelo Mancuso,Ubaldo Bonuccelli,N.J. Cairns,Andrew McQuillin,Chuanhai Cao,Gill Livingston,N Bass,John Hardy,José Brás,Rita Guerreiro,Mariet Allen,Elizabeth Fisher,Carlo Masullo,E.A. Crocco,Charles DeCarli,Gina Bisceglio,Malcolm Dick,Li Ma,Ranjan Duara,D. Evans,Angela Hodges,Martin Scherer,K.B. Fallon,Mona Riemenschneider,Reinhard Heun,M. Farlow,Steven Ferris,Markus Leber,Isabella Heuser,Galasko Dr,Ina Giegling,Marla Gearing,Michael Hüll,Geschwind Dh,J.R. Gilbert,J.C. Morris,Green Rc,Kevin Mayo,Growdon Jh,Thomas Feulner,Russell Hamilton,Dmitriy Drichel,Paul Hollingworth,C. Hulette,Hyman Bt,Rachel Marshall,Alun Meggy,Erin Abner,Georgina Menzies,Ganna Leonenko,Gyungah Jun,Detelina Grozeva,Anna Karydas,Giancarlo Russo,Frank Jessen,Kowall Nw,Bruno Vellas,J. Kramer,Emma Vardy,F. Laferla,Lah Jj,Martin Dichgans,David Mann,AS Levey,Stuart Pickering‐Brown,A.P. Lieberman,Norman Klopp,Kathryn Lunetta,Lyketsos Cg,Kevin Morgan,Kristelle Brown,Frank Martiniuk,Christopher Medway,Mash Dc,M.M. Nöthen,Eliezer Masliah,Nigel Hooper,W. McCormick,Antonio Daniele,Antony Bayer,John Gallacher,Anne McKee,Hendrik Bussche,Marek Mesulam,Carol Brayne,B. Miller,Steffi Riedel‐Heller,C Miller,J.H. Miller,Ammar Al‐Chalabi,Christopher Shaw,Jens Wiltfang,Sid O’Bryant,Eliécer Coto,J.M. Olichney,Victoria Álvarez,J. Parisi,H.L. Paulson,John Collinge,William Perry,Simon Mead,Elaine Peskind,Martin Rosser,Aimee Pierce,Natalie Ryan,Benedetta Nacmias,Huntington Potter,Sandro Sorbi,Quinn Jf,Eleonora Sacchinelli,Ashok Raj,Gianfranco Spalletta,Murray Raskind,Paola Bossù,‌Barry Reisberg,Robert Clarke,Christiane Reitz,A. Smith,Donald Warden,Gordon Wilcock,Ekaterina Rogaeva,Amalia Bruni,Rosen Hj,Maura Gallo,Rosenberg Rn,Yoav Ben‐Shlomo,Stefan Ma,Patrizia Mecocci,Pau Pástor,J. Vance,Johann Schneider,LON SCHNEIDER,Salvatore Spina,Tanzi Re,J Trojanowski,J. Troncoso,H.V. Vinters,J-P Vonsattel,Sandra Weıntraub,K. Wilhelmsen,Jennifer Williamson,T. Wingo,C.B. Wright,Lei Yu,Bennett Dj,Virginia Boccardi,PL Jager,Nick Warner,Stefan McDonough,Martin Ingelsson,Panagiotis Deloukas,Carlos Cruchaga,Caroline Graff,Rhian Gwilliam,Myriam Fornage,A Goate,Pascual Sánchez‐Juan,Najaf Amin,Nilüfer Ertekin-Taner,Claudine Berr,Stéphanie Debette,Shelly‐Ann Love,Launer Lj,Younkin Sg,Dartigues Jf,Chris Corcoran,M. Ikram,D. Dickson,Dominique Campion,JoAnn Tschanz,Helena Schmidt,Hákon Hákonarson,Ron Munger,Ryder Schmidt,Christine Broeckhoven,DeStefano Al,Lesley Jones,Haines Jl,J-F Deleuze,M Owen,V. Gudnason,Richard Mayeux,Valentina Escott‐Price,Agustín Ruiz,Andrea Ramírez,Lusheng Wang,CM Duijn,Peter Holmans,Sudha Seshadri,Julie Williams,Philippe Amouyel,Schellenberg Gd,J-C Lambert