Abstract

The aim of this research-based review is to disseminate scientific knowledge about an important FOXO3 gene and its activation by phytochemicals. The fork head box O (FOXO) transcription factor is composed of helix DNA. FOXOs are involved in metabolism, cell cycle arrest, apoptosis, energy, oxidative stress, immunity, inflammation, and stem cell maintenance symptoms that occur because of age associated diseases. Its FOXOs family consists of foxo1, foxo3, foxo4 and foxo6, but all of them are different from each other, among which FOXO3 gene involved in human longevity. FOXO3 proteins manage those genes that are associated with growth factors. To increase health span FOXO3 proteins are engaged in many physiological and pathological conditions like cardiovascular diseases, cancer, diabetes, chronic neurological diseases, and tumor suppressants. Phytochemicals, including polyphenols, seem to have potential for upregulation of the function of FOXO 3. The literature for the described study was collected by various research engines like Google Scholar, PubMed, ResearchGate, etc. Our review-based study reveals that Phenols, Polyphenols and terpenoids were found to be effective regulators of the FOXO3 gene for human longevity. Keywords: FOXO3, Tumor suppressants, Polyphenols, Oxidative stress, DNA.