Obesity is one of the major chronic diseases in which excess body fat accumulates in visceral organs. It is a chronic metabolic disease due to an imbalance between energy intake and expenditure. Various synthetic treatments are available in the market but have side effects such as Joint pain, chest tightness, tiredness, Back and stomach pain. The aim of study was to examine the anti-obesity potential of prepared polyherbal formulation (Hugonia Mystax: Blumea Lacera::1:1) in female Wistar rats. The obesity was induced by a high fat diet. Group 1 Placebo (normal control), Group 2-high fat diet (disease control), Group 3-high fat diet and orlistat (20 mg/kg for last 2 weeks, Group 4 treated with high fat diet and low dose elixir (200 mg/kg i.e. 4ml orally for last 2 weeks of study), Group 5- high fat diet and high dose elixir (400 mg/kg i.e. 8ml orally for last 2 weeks of study). At the end of study rats were subjected to evaluation of physical parameters, liver profile, serum blood glucose level and histopathology of liver and adipose tissue. The result states that formulation has the potential to work on various obesity mechanisms especially on energy intake. The result of the present study concluded that the prepared formulation has anti-obesity potential.

Effect of Polyherbal Formulation on High Fat Diet Induced Obesity in Rats