Silk-Based Hydrogels In article number 2312261, Su Ryon Shin and co-workers present that the local delivery of oxygen and a chemoattractant of stem cells via injectable, mechanically robust, and tissue-adhesive silk-based hybrid hydrogels alleviated ischemia and induced host stem cell homing at the myocardial infarction area, leading to decreased fibrotic scar formation and improved cardiac functional recovery.