Abstract

ABSTRACT Background Regional anesthesia is an alternative to opioids for pain in patients undergoing liver transplantation. Quadratus lumborum blocks may provide appropriate dermatomal coverage with an excellent safety profile. Methods Data were collected retrospectively on adult patients who underwent liver transplant at an academic medical center from 2019 to 2022 ( n = 207). The primary outcome was opioid administration during the 48 h after transplant. Results Patient demographics did not differ between groups. No association was found between patients who received a block and postoperative opioid administration ( p = 0.848). However, among patients extubated in the operating room, patients who received a block reported, on average, a 0.9‐unit lower pain score than patients who received no block ( p = 0.041). Patients who received a block were also more likely to be extubated in the operating room (87.8% block vs. 44.4% no block; p < 0.001). Conclusion Patients who underwent liver transplantation had similar postoperative opioid use whether or not they received a quadratus lumborum block. Yet, when evaluating additional factors, such as extubation, pain scores were lower in patients who received a quadratus lumborum block. This important finding supports the idea that quadratus lumborum blocks may be a safe and valuable technique for controlling postoperative pain in adult patients who undergo liver transplantation.