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The Impact of PAD4-dependent Neutrophil Extracellular Trap Formation on the Early Development of Intestinal Fibrosis in Crohn’s Disease
Authors
Gabriele Dragoni,Bo-Jun Ke
Lucia Picariello,Saeed Abdurahiman,E. Ceni,Francesca Biscu,Tommaso Mello,Simone Polvani,Tommaso Innocenti,Valérie Spalart,S. Milani,André D’Hoore,Gabriele Bislenghi,Stefano Scaringi,Bram Verstockt,Gert Hertogh,Kimberly Martinod,Andrea Galli,Gianluca Matteoli,Séverine Vermeire
+18 authors
,A. D’HoorePublished
Aug 10, 2024
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Abstract
During early phases of inflammation, activated neutrophils extrude neutrophil extracellular traps (NETs) in a PAD4-dependent manner, aggravating tissue injury and remodelling. In this study, we investigated the potential pro-fibrotic properties and signalling of NETs in Crohn's disease (CD).
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