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The Impact of PAD4-dependent Neutrophil Extracellular Tra... | ResearchHub

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Journal

Journal of Crohn s and Colitis

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DOI

10.1093/ecco-jcc/jjae121

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The Impact of PAD4-dependent Neutrophil Extracellular Trap Formation on the Early Development of Intestinal Fibrosis in Crohn’s Disease

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Authors

Gabriele Dragoni

Gabriele Dragoni•Bo-Jun Ke•Séverine Vermeire

Published

August 10, 2024

Abstract

During early phases of inflammation, activated neutrophils extrude neutrophil extracellular traps (NETs) in a PAD4-dependent manner, aggravating tissue injury and remodelling. In this study, we investigated the potential pro-fibrotic properties and signalling of NETs in Crohn's disease (CD).

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Journal

Journal of Crohn s and Colitis

Topics

DOI

10.1093/ecco-jcc/jjae121