A 60-year-old male presented with recurrent syncopes and a right-sided neck mass, due to squamous cell carcinoma. His syncopes were caused by bradycardias and hypotension, requiring transvenous pacing and vasopressors. Surgical resection and radiotherapy relieved the hemodynamic symptoms. This case report of an unusual response to presumed carotid sinus compression highlights the need for a multidisciplinary approach in addressing the etiology of reflex syncope in patients with oncological conditions.
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