Abstract

The Pragmatic Explanatory Continuum Indicator Summary (PRECIS) tool, initially published in 2009 and revised in 2015, was created to assist trialists to align their design choices with the intended purpose of their randomised controlled trial (RCT): either to guide real-world decisions between alternative interventions (pragmatic) or to test hypotheses about intervention mechanisms by minimising sources of variation (explanatory). There have been many comments, suggestions and criticisms of PRECIS-2. This summary will be used to facilitate the development of to the next revision, PRECIS-3.