Abstract

ATA FROM LARGE OUTCOMEtrials indicate that the level of glycemic control predicts cardiovascular events. 1,2n the UK Prospective Diabetes Study (UKPDS), 2 patients with lower initial glycemia had fewer adverse clinical outcomes despite similar glycemic progression.Taken together with data from the National Health and Nutrition Examination Survey IV (NHANES IV), that only 37% of adults with diabetes mellitus (DM) attain recommended levels of glycosylated hemoglobin (HbA 1c ), achieving better glycemic control should further reduce the risk of cardiovascular events. 3andomized trials comparing reninangiotensin system (RAS) blockers with ␤-blockers demonstrate that cardiovascular outcomes are improved by RAS blockers, which maintain or improve