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Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056
Authors
Sébastien Jacquemont,Aurore Curie
Randy Gollub,Maria Torrioli,Elizabeth Berry‐Kravis,Randi Hagerman,Feliciano Ramos,Kim Cornish,Yunsheng He,Charles Paulding,Giovanni Neri,Fei Chen,Nouchine Hadjikhani,Danielle Martinet,Joanne Meyer,J. Beckmann,Delange Karine,Brun Amandine,Gérald Bussy,Fabrizio Gasparini,Talita Hilse,Annette Floesser,Janice Branson,Graeme Bilbe,Donald Johns,Baltazar Gomez‐Mancilla
+24 authors
,Jacques BeckmannPublished
Jan 5, 2011
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Abstract
An antagonist for the metabotropic glutamate receptor may improve symptoms in patients with fragile X syndrome whose FMR1 promoters are fully methylated.
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