Abstract

Inflammation is an innate defense response of an organism to tissue damage which is accompanied by biological processes such as depolarization, autophagy, and endogenous bisulfite production. As a novel type of iron-dependent programmed apoptosis, ferroptosis accumulates an excessive lipid peroxide, leading to fluctuations of polarity and SO2. To study the dynamic correlation between SO2 and polarity of these two diseases is of great significance for revealing the precise regulation mechanism of inflammation and ferroptosis. In this research, a multicolor fluorescent probe BDMOB was developed by coupling a sulfur dioxide response site with push-pull electrons, realizing orange and near-infrared fluorescence emission, allowing to the simultaneous detection of polarity and SO2. With its attractive AIE and NIR properties, BDMOB is able to effectively prevent background interference and effectively solve the problem of fluorescence quenching. For the first time, the slight fluctuations in SO2 and polarity during inflammation and ferroptosis is shown by examining parameter changes during aberrant processes at the in vivo and in vitro levels. This offers fresh insights into the diagnosis and therapy of disease processes.