Abstract

Pipecolic acid is essential for the establishment of systemic acquired resistance in plants. It is synthesized in the plastid and further processed in the cytosol to its active form N-hydroxy pipecolic acid. Here we provide strong evidence that the exporter Enhanced Disease Susceptibility 5 is required for the biosynthesis of not only salicylic acid, but also N-hydroxy pipecolic acid, suggesting that it represents a convergent point of plant immunity.