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The Somatic Genomic Landscape of Glioblastoma
Authors
Cameron Brennan,Roel Verhaak
Aaron McKenna,Benito Campos,Houtan Noushmehr,Sofie Salama,Siyuan Zheng,Debyani Chakravarty,Zack Sanborn,Samuel Berman,Rameen Beroukhim,Brady Bernard,Chang‐Jiun Wu,Giannicola Genovese,Ilya Shmulevich,Jill Barnholtz‐Sloan,Lihua Zou,Rahulsimham Vegesna,Sachet Shukla,Giovanni Ciriello,W. Yung,Wei Zhang,Carrie Sougnez,Tom Mikkelsen,Kenneth Aldape,Darell Bigner,Erwin Meir,Michael Prados,Andrew Sloan,Keith Black,Jennifer Eschbacher,Gaetano Finocchiaro,William Friedman,David Andrews,Abhijit Guha,Mary Iacocca,Brian O’Neill,Greg Foltz,Jerome Myers,Daniel Weisenberger,Robert Penny,Raju Kucherlapati,Charles Perou,D. Hayes,Richard Gibbs,Marco Marra,Gordon Mills,Sı́lvia Beà,Paul Spellman,Richard Wilson,Chris Sander,John Weinstein,Matthew Meyerson,Stacey Gabriel,Peter Laird,David Haussler,Gad Getz,Lynda Chin,Christopher Benz,Wendi Barrett,Quinn Ostrom,Yingli Wolinsky,Bikash Bose,Paul Boulos,Madgy Boulos,Jenn Brown,Christine Czerinski,Matthew Eppley,Thelma Kempista,Teresa Kitko,Yakov Koyfman,Brenda Rabeno,Pawan Rastogi,Michael Sugarman,Patricia Swanson,Kennedy Yalamanchii,Ilana Otey,Yingchun Liu,Yonghong Xiao,J. Auman,Peng‐Chieh Chen,Angela Hadjipanayis,Eunjung Lee,Semin Lee,Peter Park,Jonathan Seidman,Lixing Yang,Steven Kalkanis,Laila Poisson,Aditya Raghunathan,Lisa Scarpace,Ryan Bressler,Andrea Eakin,Lisa Iype,Richard Kreisberg,Kalle Leinonen,Sheila Reynolds,Hector Rovira,Vésteinn Thórsson,Matti Annala,Joseph Paulauskis,Erin Curley,M. Hatfield,David Mallery,Scott Morris,Troy Shelton,Candace Shelton,Mark Sherman,Peggy Yena,Lucia Cuppini,Francesco DiMeco,Marica Eoli,Emanuela Maderna,Bianca Pollo,Marco Saini,Saianand Balu,Katherine Hoadley,Ling Li,C. Miller,Yan Shi,Michael Topal,Junyuan Wu,Gavin Dunn,Caterina Giannini,Bülent Aksoy,Yevgeniy Antipin,Laetitia Borsu,Ethan Cerami,Jianjiong Gao,Benjamin Groß,Anders Skanderup,Marc Ladanyi,Alex Lash,Yupu Liang,Boris Reva,Nikolaus Schultz,Ronglai Shen,Nicholas Socci,Agnès Viale,Martin Ferguson,Qing‐Rong Chen,John Demchok,Laura Dillon,Kenna Shaw,Margi Sheth,Roy Tarnuzzer,Zhining Wang,Liming Yang,Tanja Davidsen,Mark Guyer,Bradley Ozenberger,Heidi Sofia,Julie Bergsten,John Eckman,Jodi Harr,Christine Smith,Kelly Tucker,Cindy Winemiller,Leigh Zach,Julia Ljubimova,Greg Eley,Brenda Ayala,Mark Jensen,A Kahn,Todd Pihl,David Pot,Yunhu Wan,Nathan Hansen,Parvi Hothi,Biaoyang Lin,Nameeta Shah,Jae‐Geun Yoon,Ching Lau,Michael Berens,Kristin Ardlie,Scott Carter,Andrew Cherniack,M. Noble,Juok Cho,Kristian Cibulskis,Daniel DiCara,Scott Frazer,Nils Gehlenborg,Jeff Gentry,David Heiman,Jaegil Kim,Rui Jing,Michael Lawrence,Pei Lin,Will Mallard,Robert Onofrio,Gordon Saksena,Steven Schumacher,Petar Stojanov,Barbara Tabak,Doug Voet,Hailei Zhang,Nathan Dees,Jun Li,Lucinda Fulton,Robert Fulton,Krishna-Latha Kanchi,Elaine Mardis,Stephen Baylin,Larry Harshyne,Mark Cohen,Karen Devine,Scott VandenBerg,Mitchel Berger,Daniel Carlin,Brian Craft,Kyle Ellrott,Mary Goldman,Theodore Goldstein,Mia Grifford,Xiaotu Ma,Sam Ng,Joshua Stuart,Teresa Swatloski,Peter Waltman,Jing Zhu,Robin Foss,Barbara Frentzen,Raquel McTiernan,Anthony Yachnis,Yong Mao,Rehan Akbani,Oliver Bögler,Gregory Fuller,Wenbin Liu,Yuexin Liu,Yiling Lu,Alexei Protopopov,Xiaojia Ren,Youting Sun,Jianhua Zhang,Ken Chen,Moiz Bootwalla,Phillip Lai,Youjia Li,David Berg,David Gutmann,Norman Lehman,Daniel Brat,Jeffrey Olson,Gena Mastrogianakis,Narra Devi,Zhaobin Zhang,Eric Lipp,Roger McLendon,J. Sanborn
+249 authors
,Eric LanderJournal
Published
Oct 1, 2013
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Abstract
Summary
We describe the landscape of somatic genomic alterations based on multidimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated genes as well as complex rearrangements of signature receptors, including EGFR and PDGFRA. TERT promoter mutations are shown to correlate with elevated mRNA expression, supporting a role in telomerase reactivation. Correlative analyses confirm that the survival advantage of the proneural subtype is conferred by the G-CIMP phenotype, and MGMT DNA methylation may be a predictive biomarker for treatment response only in classical subtype GBM. Integrative analysis of genomic and proteomic profiles challenges the notion of therapeutic inhibition of a pathway as an alternative to inhibition of the target itself. These data will facilitate the discovery of therapeutic and diagnostic target candidates, the validation of research and clinical observations and the generation of unanticipated hypotheses that can advance our molecular understanding of this lethal cancer.Paper PDF
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