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Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
Authors
Daniel Brat,Roel Verhaak
Kenneth Aldape,W. Yung,Sofie Salama,Lee Cooper,Esther Rheinbay,C. Miller,Mark Vitucci,Olena Morozova,Robert Holt,Houtan Noushmehr,Peter Laird,Andrew Mungall,Rehan Akbani,Jason Huse,Giovanni Ciriello,Laila Poisson,Jill Barnholtz‐Sloan,Mitchel Berger,Cameron Brennan,Rivka Colen,Howard Colman,Adam Flanders,Caterina Giannini,Mia Grifford,Antonio Iavarone,Rajan Jain,Isaac Joseph,Jaegil Kim,Katayoon Kasaian,Tom Mikkelsen,Bradley Murray,Brian O’Neill,Lior Pachter,Donald Parsons,Carrie Sougnez,Erik Sulman,Scott VandenBerg,Erwin Meir,Andreas Deimling,Hailei Zhang,Daniel Crain,Kevin Lau,David Mallery,Scott Morris,Joseph Paulauskis,Robert Penny,Troy Shelton,Mark Sherman,Peggy Yena,Aaron Black,Jay Bowen,Katie Dicostanzo,Julie Gastier‐Foster,Kristen Leraas,Tara Lichtenberg,Christopher Pierson,Nilsa Ramirez,Cynthia Taylor,Stephanie Weaver,Lisa Wise,Erik Zmuda,Tanja Davidsen,John Demchok,Greg Eley,Martin Ferguson,Carolyn Hutter,Kenna Shaw,Bradley Ozenberger,Margi Sheth,Heidi Sofia,Roy Tarnuzzer,Zhining Wang,Liming Yang,Jean Zenklusen,Brenda Ayala,Julien Baboud,Sudha Chudamani,Mark Jensen,Jia Liu,Todd Pihl,Rohini Raman,Yunhu Wan,Ye Wu,Adrian Ally,J. Auman,Miruna Balasundaram,Saianand Balu,Stephen Baylin,Rameen Beroukhim,Moiz Bootwalla,Reanne Bowlby,Christopher Bristow,Denise Brooks,Yaron Butterfield,Rebecca Carlsen,Scott Carter,Lynda Chin,Andy Chu,Eric Chuah,Kristian Cibulskis,Amanda Clarke,Simon Coetzee,Noreen Dhalla,Timothy Fennell,Sheila Fisher,Stacey Gabriel,Gad Getz,Richard Gibbs,Ranabir Guin,Angela Hadjipanayis,D. Hayes,Toshinori Hinoue,Katherine Hoadley,Alan Hoyle,Joshua Stuart,Steven Jones,Corbin Jones,Raju Kucherlapati,Phillip Lai,Sı́lvia Beà,Semin Lee,Lee Lichtenstein,Yussanne Ma,Dennis Maglinte,Harshad Mahadeshwar,Marco Marra,Michael Mayo,Shaowu Meng,Matthew Meyerson,Piotr Mieczkowski,Richard Moore,Lisle Mose,Angeliki Pantazi,Michael Parfenov,Peter Park,Joel Parker,Charles Perou,Alexei Protopopov,Xiaojia Ren,Jeffrey Roach,Thaís Sabedot,Jacqueline Schein,Steven Schumacher,Jonathan Seidman,Sahil Seth,Hui Shen,Janae Simons,Payal Sipahimalani,Matthew Soloway,Xingzhi Song,Huandong Sun,Barbara Tabak,Angela Tam,Donghui Tan,Jiabin Tang,Nina Thiessen,Timothy Triche,David Berg,Umadevi Veluvolu,Stephen Waring,Daniel Weisenberger,Matthew Wilkerson,Tina Wong,Junyuan Wu,Xi Liu,Andrew Xu,Lixing Yang,Travis Zack,Jianhua Zhang,Bülent Aksoy,Harindra Arachchi,Chris Benz,Brady Bernard,Daniel Carlin,Juok Cho,Daniel DiCara,Scott Frazer,Gregory Fuller,Jianjiong Gao,Nils Gehlenborg,David Haussler,David Heiman,Lisa Iype,Anders Skanderup,Zhenlin Ju,Sol Katzman,Hoon Kim,Theo Knijnenburg,Richard Kreisberg,Michael Lawrence,William Lee,Kalle Leinonen,Pei Lin,Shiyun Ling,Wenbin Liu,Yingchun Liu,Yuexin Liu,Yiling Lu,Gordon Mills,Sam Ng,Michael Noble,Evan Paull,Arvind Rao,Sheila Reynolds,Gordon Saksena,Zack Sanborn,Chris Sander,Nikolaus Schultz,Yasin Şenbabaoğlu,Ronglai Shen,Ilya Shmulevich,Rileen Sinha,S. Sumer,Yichao Sun,Natalie Tasman,Justin Taylor,Doug Voet,Nils Weinhold,John Weinstein,Da Yang,Kosuke Yoshihara,Yukui Zhang,Wei Zhang,Lihua Zou,Ty Abel,Sara Sadeghi,Mark Cohen,Jenny Eschbacher,Eyas Hattab,Aditya Raghunathan,Matthew Schniederjan,Dina Aziz,Gene Barnett,Wendi Barrett,Darell Bigner,Lori Boice,Cathy Brewer,Chiara Calatozzolo,Benito Campos,Carlos Carlotti,Timothy Chan,Lucia Cuppini,Erin Curley,Stefania Cuzzubbo,Karen Devine,Francesco DiMeco,Rebecca Duell,J. Elder,Ashley Fehrenbach,Gaetano Finocchiaro,William Friedman,Jordonna Fulop,Johanna Gardner,Beth Hermes,Christel Herold‐Mende,Christine Jungk,Ady Kendler,Norman Lehman,Eric Lipp,Ouida Liu,Randy Mandt,Mary McGraw,Roger McLendon,Christopher McPherson,Luciano Neder,Phuong Nguyen,Ardene Noss,R. Nunziata,Quinn Ostrom,Cheryl Palmer,Alessandro Perin,Bianca Pollo,Potapov Aa,Olga Potapova,W. Rathmell,Д. Ротин,Lisa Scarpace,Cathy Schilero,Kelly Senecal,Kristen Shimmel,Vsevolod Shurkhay,Suzanne Sifri,Rosy Singh,Andrew Sloan,Kathy Smolenski,Susan Staugaitis,Ruth Steele,Leigh Thorne,Daniela Tirapelli,Andreas Unterberg,Mounica Vallurupalli,Sheng Wang,Ronald Warnick,Cecilia Williams,Yingli Wolinsky,Sue Bell,Mara Rosenberg,Chip Stewart,Franklin Huang,Jonna Grimsby,Amie Radenbaugh,Jianan Zhang,S. Weaver,A. Robertson,Andrew Cherniack,L. Sylvia,D. Parsons,Linghua Wang
+308 authors
,Arnoud BootPublished
Jun 11, 2015
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Abstract
Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior that is not adequately predicted on the basis of histologic class. Some are indolent; others quickly progress to glioblastoma. The uncertainty is compounded by interobserver variability in histologic diagnosis. Mutations in IDH, TP53, and ATRX and codeletion of chromosome arms 1p and 19q (1p/19q codeletion) have been implicated as clinically relevant markers of lower-grade gliomas.
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