Abstract

Animals continously adapt their behavior to balance survival and fulfilling essential needs. This balancing act involves prioritization of safety over the pursuit of other needs. However, the specific deep brain circuits that regulate safety-seeking behaviors in conjuction with motor circuits remain poorly understood. Here we identify a class of glutamatergic neurons in the lateral hypothalamic area (LHA) that target the midbrain locomotor-promoting pedunculopontine nucleus (PPN). Upon activation, this LHA-PPN pathway orchestrates context-dependent locomotion, prioritizing safety-directed movement over other essential needs such as foraging or mating. Remarkably, the neuronal activity of these circuits correlates directly with safety-seeking behavior. These circuits may respond to both intrinsic and external cues, playing a pivotal role in ensuring survival. Our findings uncover a circuit motif within the lateral hypothalamus that when recruited, prioritizes critical needs through the recruitment of an appropriate motor action.