Paper

Paper

Changelog Terms Privacy Issues Docs Support Foundation About

Hypothalamic Polypeptide That Inhibits the Secretion of I... | ResearchHub

Paper

Paper

Supporters

Support the authors with ResearchCoin

Journal

Topics

Internal Medicine

DOI

10.1126/science.179.4068.77

Changelog Terms Privacy Issues Docs Support Foundation About

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

0

Authors

Paul Brazeau

Paul Brazeau•Jean Rivier•Roger Guillemin

Published

January 5, 1973

Abstract

A peptide has been isolated from ovine hypothalamus which, at 1 × 10 -9 M , inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. Its structure is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH. The synthetic replicate is biologically active.

Supporters

Support the authors with ResearchCoin

Journal

Topics

Internal Medicine

DOI

10.1126/science.179.4068.77