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Discovery and refinement of loci associated with lipid levels

Authors
Cristen Willer,Ellen Schmidt
Sebanti Sengupta,Gina Peloso,Stefan Gustafsson,Stavroula Kanoni,Andrea Ganna,Ming‐Huei Chen,Martin Buchkovich,Samia Mora,J. Beckmann,Jennifer Bragg‐Gresham,Hsing‐Yi Chang,Ayşe Demirkan,Heleen Hertog,Ron Do,Andrew Brown,Georg Ehret,Tõnu Esko,Mary Feitosa,Teresa Ferreira,Krista Fischer,Pierre Fontanillas,Ross Fraser,Daniel Freitag,Deepti Gurdasani,Kauko Heikkilä,Elina Hyppönen,Aaron Isaacs,Anne Jackson,Åsa Johansson,Toby Johnson,Marika Kaakinen,Johannes Kettunen,Marcus Kleber,Xiaohui Li,Jian’an Luan,Leo‐Pekka Lyytikäinen,Patrik Magnusson,Massimo Mangino,Reedik Mägi,May Montasser,Martina Müller‐Nurasyid,Ilja Nolte,Jeffrey O’Connell,Cameron Palmer,Markus Perola,Ann Petersen,Serena Sanna,Richa Saxena,Susan Service,Sonia Shah,Dmitry Shungin,Carlo Sidore,Ci Song,Rona Strawbridge,Ida Surakka,Toshiko Tanaka,Jan Staessen,Guðmar Þorleifsson,Evita Herik,Benjamin Voight,Kelly Volcik,Lindsay Waite,Andrew Wong,Wei Zheng,Weihua Zhang,Devin Absher,Gershim Asiki,Inês Barroso,Latonya Been,Jennifer Bolton,Lori Bonnycastle,Paolo Brambilla,Mary Burnett,Giancarlo Cesana,Maria Dimitriou,Alex Doney,Angela Döring,Paul Elliott,Stephen Epstein,Guðmundur Eyjólfsson,Bruna Gigante,Mark Goodarzi,Harald Grallert,Martha Gravito,Christopher Mathew,Göran Hallmans,Anna-Liisa Hartikainen,Caroline Hayward,Dena Hernández,Andrew Hicks,Hilma Hólm,Yi-Jen Hung,Thomas Meitinger,Michelle Jones,Pontiano Kaleebu,John Kastelein,Kay‐Tee Khaw,Eric Kim,Norman Klopp,José Krieger,Meena Kumari,Claudia Langenberg,Terho Lehtimäki,Shih-Yi Lin,Jaana Lindström,Ruth Loos,François Mach,Wendy McArdle,Christa Meisinger,Braxton Mitchell,Gabrielle Müller,Ramaiah Nagaraja,Narisu Narisu,Tuomo Nieminen,Rebecca Nsubuga,Ísleifur Ólafsson,Ken Ong,Aarno Palotie,Theodore Papamarkou,Cristina Pomilla,Anneli Pouta,Daniel Rader,Muredach Reilly,Paul Franks,Fernando Rivadeneira,Igor Rudan,Aimo Ruokonen,Nilesh Samani,Hubert Scharnagl,Janet Seeley,Kaisa Silander,Alena Stančáková,Kathleen Stirrups,Amy Swift,Laurence Tiret,André Uitterlinden,L. Pelt,Sailaja Vedantam,Nicholas Wainwright,Cisca Wijmenga,Sarah Wild,Gonneke Willemsen,Tom Gaunt,James Wilson,Elizabeth Young,Jing Zhao,Linda Adair,Dominique Arveiler,Themistocles Assimes,Stefania Bandinelli,Franklyn Bennett,Murielle Bochud,Bernhard Boehm,Dorret Boomsma,Ingrid Borecki,Stefan Bornstein,Pascal Bovet,Michel Burnier,Harry Hemingway,Aravinda Chakravarti,John Chambers,Yii-Der Chen,Francis Collins,Richard Cooper,John Danesh,George Smith,Ulf Fairé,Alan Feranil,Jean Ferrières,Luigi Ferrucci,Nelson Freimer,Christian Gieger,Leif Groop,Vilmundur Guðnason,Ulf Gyllensten,Anders Hamsten,Tamara Harris,Aroon Hingorani,Joel Hirschhorn,Albert Hofman,G. Hovingh,Victoria Cortessis,Steve Humphries,Steven Kahn,Kristian Hveem,Carlos Iribarren,Marjo‐Riitta Järvelin,Antti Jula,Mika Kähönen,Jaakko Kaprio,Antero Kesäniemi,Mika Kivimäki,Jaspal Kooner,Peter Koudstaal,Ronald Krauss,Bagher Larijani,Kirsten Kyvik,Markku Laakso,Timo Lakka,Lars Lind,Cecilia Lindgren,Nicholas Martin,Winfried März,Mark McCarthy,Colin Chapman,Pierre Meneton,Andres Metspalu,Leena Moilanen,Andrew Morris,Patricia Munroe,Inger Njølstad,Nancy Pedersen,Chris Power,Peter Pramstaller,Jackie Price,Bruce Psaty,Thomas Quertermous,Rainer Rauramaa,Danish Saleheen,Veikko Salomaa,Dharambir Sanghera,Abhijit Sen,Peter Schwarz,Wayne Sheu,Alan Shuldiner,Agneta Siegbahn,Tim Spector,Kāri Stefánsson,David Strachan,Bamidele Tayo,Elena Tremoli,Jaakko Tuomilehto,Matti Uusitupa,Cornelia Duijn,Péter Vollenweider,Lars Wallentin,Nicholas Wareham,John Whitfield,Bruce Wolffenbuttel,José Ordovás,Eric Boerwinkle,Colin Palmer,Unnur Þorsteinsdóttir,Daniel Chasman,Jerome Rotter,Samuli Ripatti,L. Cupples,Manjinder Sandhu,Stephen Rich,Michael Boehnke,Panos Deloukas,Sekar Kathiresan,Karen Mohlke,Erik Ingelsson,Gonçalo Abecasis,Ming-Huei Chen,Jacques Beckmann,Evelin Mihailov
+258 authors
,Gudmundur Eyjolfsson
Published
Oct 6, 2013
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Abstract

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

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