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New loci associated with kidney function and chronic kidney disease

Authors
Anna Köttgen,Cristian Pattaro
Carsten Böger,Christian Fuchsberger,Matthias Olden,Nicole Glazer,Afshin Parsa,Xiaoyi Gao,Qiong Yang,Albert Hofman,Jeffrey O’Connell,Man Li,Helena Schmidt,Toshiko Tanaka,Aaron Isaacs,Shamika Ketkar,Shih-Jen Hwang,Andrew Johnson,Abbas Dehghan,Alexander Teumer,Guillaume Paré,Elizabeth Atkinson,Tanja Zeller,Kirsten Kyvik,Marilyn Cornelis,Nicole Probst‐Hensch,Florian Kronenberg,Anke Tönjes,Caroline Hayward,Thor Aspelund,Guðný Eiríksdóttir,Lenore Launer,Tamara Harris,Evadnie Rampersaud,Braxton Mitchell,Dan Arking,Eric Boerwinkle,Maksim Struchalin,Margherita Cavalieri,Andrew Hattersley,Francesco Giallauria,Jeffrey Metter,Ian Boer,Talin Haritunians,Thomas Meitinger,David Siscovick,Bruce Psaty,M Zillikens,Ben Oostra,Mary Feitosa,Michael Province,Mariza Andrade,Stephen Turner,Arne Schillert,Andreas Ziegler,Philipp Wild,Renate Schnabel,Sandra Wilde,Thomas Münzel,Tennille Leak,Norman Klopp,Christa Meisinger,H.‐Erich Wichmann,Wolfgang Köenig,Lina Zgaga,Tatijana Zemunik,Ivana Kolčić,Cosetta Minelli,Frank Hu,Åsa Johansson,Wilmar Igl,Adam Ameur,Sarah Wild,Alan Wright,Harry Hemingway,David Ellinghaus,Stefan Schreiber,Yurii Aulchenko,Janine Felix,Fernando Rivadeneira,André Uitterlinden,Medea Imboden,Dorothea Nitsch,Anita Kloss‐Brandstätter,Barbara Kollerits,Lyudmyla Kedenko,Reedik Mägi,Michael Stümvoll,Péter Kovács,Mladen Boban,Susan Campbell,Karlhans Endlich,Henry Völzke,Heyo Kroemer,Matthias Nauck,Uwe Völker,Ozren Polašek,Véronique Vitart,Sunita Badola,Alexander Parker,Paul Franks,Sharon Kardia,Stefan Blankenberg,Yongmei Liu,Gary Curhan,André Franke,Thierry Rochat,Bernhard Paulweber,Inga Prokopenko,Wei Wang,Vilmundur Guðnason,Alan Shuldiner,Josef Coresh,Reinhold Schmidt,Luigi Ferrucci,Michael Shlipak,Cornelia Duijn,Ingrid Borecki,Bernhard Krämer,Igor Rudan,Ulf Gyllensten,James Wilson,Jacqueline Center,Peter Pramstaller,Rainer Rettig,Nick Hastie,Daniel Chasman,W.H. Kao,Iris Heid,Shih Hwang,H‐Erich Wichmann
+129 authors
,Wolfgang Koenig
Published
Apr 11, 2010
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Abstract

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

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