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Diphosphonates Inhibit Hydroxyapatite Dissolution in vitr... | ResearchHub

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Cancer Oncology

DOI

10.1126/science.165.3899.1262

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Diphosphonates Inhibit Hydroxyapatite Dissolution in vitro and Bone Resorption in Tissue Culture and in vivo

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Authors

H. Fleisch

H. Fleisch•R. Graham•Marion Francis

Published

September 19, 1969

Abstract

Two diphosphonates containing the P-C-P bond, Cl(2)C(PO(3)HNa)(2), and H(2)C(PO(3)HNa)(2) retard the rate of dissolution of apatite crystals in vitro. They inhibit bone resorption induced by parathyroid extract in mouse calvaria in tissue culture and in thyroparathyroidectomized rats in vivo.

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Journal

Topics

Cancer Oncology

DOI

10.1126/science.165.3899.1262