Background: Antioxidants may protect the aging brain against oxidative damage associated with pathological changes of Alzheimer disease (AD).Objective: To examine the relationship between antioxidant supplement use and risk of AD.Design: Cross-sectional and prospective study of dementia.Elderly (65 years or older) county residents were assessed in 1995 to 1997 for prevalent dementia and AD, and again in 1998 to 2000 for incident illness.Supplement use was ascertained at the first contact.Setting: Cache County

Reduced Risk of Alzheimer Disease in Users of Antioxidant Vitamin Supplements