Abstract

Stressful experiences modulate neuro-circuitry function, and the temporal trajectory of these alterations, elapsing from early disturbances to late recovery, heavily influences resilience for psychopathology. In our previous work, we found that sustainability of subjective stress feeling following an acute social stressor, corresponded to neural stress response as indicated by resting-state functional connectivity (rsFC). In particular, we found that sustained enhancement of amygdala-hippocampus rsFC, for as long as 2 hours following lab stress induction, anti-correlated with faster recovery in stress feelings (Vaisvaser et al., 2013, 2016). Nevertheless, it is yet unknown if such acute rsFC changes could also mark long-term recovery from traumatic life stress.