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TREM2 mutations implicated in neurodegeneration impair ce... | ResearchHub

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Paper

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Journal

Science Translational Medicine

Topics

DOI

10.1126/scitranslmed.3009093

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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

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Authors

Gernot Kleinberger

Gernot Kleinberger•Yoshinori Yamanishi•Christian Haass

Published

July 2, 2014

Abstract

Loss of TREM2 function impairs phagocytosis and correlates with decreased soluble TREM2 in biological fluids of patients with neurodegenerative disorders.

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Journal

Science Translational Medicine

Topics

DOI

10.1126/scitranslmed.3009093