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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
Authors
Gernot Kleinberger,Yoshinori Yamanishi
Marc Suárez‐Calvet,Eva Czirr,Ebba Lohmann,Elise Cuyvers,Hanne Struyfs,Nadine Pettkus,Andrea Wenninger-Weinzierl,Fargol Mazaheri,Sabina Tahirović,Alberto Lleó,Daniel Alcolea,Juan Fortea,Michael Willem,Sven Lammich,José Molinuevo,Raquel Sánchez‐Valle,Anna Antonell,Alfredo Ramı́rez,Michael Heneka,Kristel Sleegers,Julie Zee,Jean‐Jacques Martin,Sebastiaan Engelborghs,Aslı Demirtaş-Tatlıdede,Henrik Zetterberg,Christine Broeckhoven,Hakan Gürvıt,Tony Wyss‐Coray,John Hardy,Marco Colonna
+30 authors
,Christian HaassPublished
Jul 2, 2014
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Abstract
Loss of TREM2 function impairs phagocytosis and correlates with decreased soluble TREM2 in biological fluids of patients with neurodegenerative disorders.
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