Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.

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Journal

Journal of Clinical Investigation

Topics

Chemistry

Biochemistry

Medicine

Internal Medicine

Endocrinology

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DOI

10.1172/jci915