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Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
Authors
Florian Zink,Simon Stacey
Gudmundur Norddahl,Michael Frigge,O. Magnusson,Ingileif Jónsdóttir,Thorgeir Thorgeirsson,Ásgeir Sigurðsson,Sigurjón Guðjónsson,Jūlı́us Guðmundsson,Jón Jónasson,Laufey Tryggvadóttír,Þorvaldur Jónsson,Agnar Helgason,Arnaldur Gylfason,Patrick Sulem,Þórunn Rafnar,Unnur Þorsteinsdóttir,Daníel Guðbjartsson,Gísli Másson,Augustine Kong,Kāri Stefánsson,Ólafur Magnússon
+21 authors
,Thorunn RafnarJournal
Published
May 9, 2017
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Abstract
Key Points Whole-genome sequencing of 11 262 Icelanders reveals that clonal hematopoiesis is very common in the elderly. Somatic mutation of some genes is strongly associated with clonal hematopoiesis, but in most cases, no driver mutations were evident.
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