Abstract

The objective of this study is to obtain precise medication delivery by combining the drug xovoltib with chitosan nanoparticles that are synthesized from the cuttlebone of sepia. The effectiveness of this drug delivery system will be evaluated by examining its ability to inhibit the growth of cancer cells using the MCF-7 cell line. This study synthesized chitosan from the cuttlebone of sepia and complexed it with Tri Polyphosphate to form Chitosan-Tri Poly phosphate-nanoparticles (CS-TPP-NPS) using the ionotropic gelation method. The UV-visible absorption study showed a strong characteristic band ranging between 200–800 nm. The 2θ value at 20.0 degrees and 20.63 degrees indicates the crystalline nature of CS-TPP-NPS loaded with xovoltib. HR-SEM image but the morphology of chitosan nanoparticles was magnified with a high voltage of 20,000 KV and observed as spherical, porous and smooth. The in vitro drug delivery of xovoltib-loaded CS-TPP was tested against MCF-7 which had lowered the cell viability rate at 300 µl/mL.