Abstract

Background: Neuromyelitis optica (NMO) is often associated with other clinical or serological markers of non-organ-specific autoimmunity.Objective: ToevaluatetherelationshipbetweenNMOspectrum disorders (NMOSDs), including NMO, longitudinally extensive transverse myelitis, and recurrent optic neuritis, and autoimmune disease.We concentrated on the association with systemic lupus erythematosus (SLE), Sjo ¨gren syndrome (SS), or serological evidence of these disorders, which commonly is a source of diagnostic confusion.